Degranulation of human neutrophils after exposure to bacterial phospholipase C

  • T. K. Wazny
  • N. Mummaw
  • B. Styrt


Because an endogenous phospholipase C (PLC) participates in neutrophil activation and because many bacterial pathogens produce PLCs, these studies examined the effect of PLC fromBacillus cereus on the release of the granule enzyme lysozyme from human neutrophils.Bacillus cereus PLC caused dose-dependent lysozyme release, and combined stimulation of neutrophils with PLC and fluoride led to increased secretion. Stimulation of neutrophil degranulation is a potential contributing factor for tissue damage in infections caused by PLC-producing organisms.


Internal Medicine Fluoride Tissue Damage Lysozyme Contribute Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1990

Authors and Affiliations

  • T. K. Wazny
    • 1
  • N. Mummaw
    • 1
  • B. Styrt
    • 1
    • 2
  1. 1.Department of MedicineMichigan State UniversityEast LansingUSA
  2. 2.Department of Microbiology and Public HealthMichigan State UniversityEast LansingUSA

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