Differential effects of bismuth and salicylate salts on the antibiotic susceptibility ofPseudomonas aeruginosa

  • P. Domenico
  • R. O'Leary
  • B. A. Cunha


The influence of salicylate or bismuth salts on antibiotic action againstPseudomonas aeruginosa was assessed in broth cultures. Sodium salicylate (2.5 mM) had no significant effect on the activity of any antibiotic tested. In contrast, bismuth compounds (0.5 mM) produced a significant change in the inhibitory activity of several antibiotics against all strains. Bismuth salts reduced imipenem activity by up to 20-fold, enhanced gentamicin or amikacin activity three to five-fold, and enhanced cefpirome or cefepime activity by as much as 10-fold against antibiotic-sensitive and resistant strains. Bismuth salts had little effect on cefoperazone, ceftazidime, or mezlocillin activity. Combining bismuth salts with aminoglycosides or fourth-generation cephalosporin antibiotics may help to combat the growing problem of resistantPseudomonas aeruginosa.


Bismuth Gentamicin Cephalosporin Salicylate Aminoglycosides 
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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • P. Domenico
    • 1
  • R. O'Leary
    • 2
  • B. A. Cunha
    • 1
  1. 1.Infectious Disease DivisionWinthrop-University HospitalMineolaUSA
  2. 2.State University of New York School of Medicine at Stony BrookNew YorkUSA

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