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, Volume 15, Issue 5–6, pp 588–593

Cellular distribution of dexamethasone in rabbit spleen and lymph nodes

  • Andrei N. Tchernitchin
  • M. Antonieta Castrillón
  • Angel Rodríguez
Immunosuppression and Inflammation Editorial

Abstract

The binding of tritiated dexamethasone by rabbit spleen and lymph nodes was studiedin vivo by dry radioautography. The labeled glucocorticoid was found in the surface and cytoplasm of eosinophil leukocytes and in the nuclei of reticular cells, plasmocytes, endothelial cells and macrophages, but not in lymphocytes, lymphoblasts or plasmoblasts. Additional administration of excess of excess of non-radioactive dexamethasone suppressed this labeling. The findings are discussed in relation to the mechanism of action of glucocorticoids in lymphoid organs.

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • Andrei N. Tchernitchin
    • 1
  • M. Antonieta Castrillón
    • 1
  • Angel Rodríguez
    • 1
  1. 1.Laboratory of Experimental Endocrinology, Department of Experimental MorphologyUniversity of Chile Medical SchoolSantiagoChile

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