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, Volume 9, Issue 3, pp 244–247 | Cite as

Inhibition of diamine oxidase by antihistaminic agents and related drugs

  • Alessandro Finazzi-Agrò
  • Giovanni Floris
  • Maria Benedetta Fadda
  • Carlo Crifò
Histamine and Kinins


Various drugs were tested as inhibitors of diamine oxidase on the basis of chemical relationships to the enzyme substrates.

It was found that serotonine tryptamine and phenformin are good competitive inhibitors while cimetidine and pheniprazine are non-competitive inhibitors. Other antihistaminic drugs like promethazine are less powerful inhibitors.


Cimetidine Diamine Competitive Inhibitor Tryptamine Promethazine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser-Verlag 1979

Authors and Affiliations

  • Alessandro Finazzi-Agrò
    • 1
  • Giovanni Floris
    • 1
  • Maria Benedetta Fadda
    • 1
  • Carlo Crifò
    • 1
  1. 1.Libero Istituto Universitario di Medicina e ChirurgiaL'Aquila ed Istituto di Chimica Biologica dell' Università di CagliariItaly

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