Inhibition of diamine oxidase by antihistaminic agents and related drugs
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Various drugs were tested as inhibitors of diamine oxidase on the basis of chemical relationships to the enzyme substrates.
It was found that serotonine tryptamine and phenformin are good competitive inhibitors while cimetidine and pheniprazine are non-competitive inhibitors. Other antihistaminic drugs like promethazine are less powerful inhibitors.
KeywordsCimetidine Diamine Competitive Inhibitor Tryptamine Promethazine
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- C.W. Lin andS.D. Kirley,Human Placental and Tumour Histamines, in:Proteins of Biological Fluids, vol 24 (Ed. H. Peeters; Pergamon Press, Oxford, 1976), p. 103.Google Scholar
- B. Mondovì, G. Rotilio, M.T. Costa andA. Finazzi-Agrò,Diamine Oxidase (Pig Kidney), inMethods in Enzymology, vol. 17B (Eds. H. Tabor and C.W. Tabor; Academic Press, New York, 1971), pp. 735–740.Google Scholar
- H.E. Mahler andE.H. Cordes,Biological Chemistry (Harper-Row, London, 1966), p. 257.Google Scholar
- E.A. Zeller,Diamine Oxidases, in:The Enzymes, vol. 8 (Eds. P.D. Boyer, H. Lardy, and K. Myrbäck; Academic Press New York, 1963), pp. 313–351.Google Scholar
- W. Lorenz, M. Thermann, H. Hamelmann, A. Schmal, D. Maroske, H.J. Reimann, J. Kusche, F. Schingale, P. Dormann andP. Keck,Influence of H 1- and H2-Receptor Antagonists on the Effects of Histamine in the Circulatory System and on Plasma Histamine Levels, in:International Symposium on Histamine H 2-Receptor Antagonists (Eds. C.J. Wood and M.H. Simkins; Smith, Kline & French, London, 1973), pp. 151–163.Google Scholar