Agents and Actions

, Volume 12, Issue 4, pp 508–515 | Cite as

Anti-inflammatory and irritant activities of curcumin analogues in rats

  • A. Mukhopadhyay
  • N. Basu
  • N. Ghatak
  • P. K. Gujral
Immunosuppression and Inflammation

Abstract

The anti-inflammatory activity of curcumin (C), sodium curcuminate (NaC), diacetyl curcumin (DAC), triethyl curcumin (TEC), tetrahydro curcumin (THC) and ferulic acid (FA) was compared with that of phenylbutazone (PB) using the carrageenin-induced rat paw edema and cotton pellet granuloma tests. The rank order of potencies of curcumin analogues and PB in carrageenininduced inflammation were NaC>THC>C>PB>TEC. The curcumin analogues decreased carrageenin-induced paw edema at low doses, however, at higher doses this effect was partially reversed. FA and DAC were devoid of antiinflammatory activity. Curcumin analogues were less effective in inhibiting the granulomatous tissue formation. Maximum activity was observed with TEC whereas C, NaC and PB were almost half as effective as TEC. C and NaC possess both anti-inflammatory and irritant properties as was evident from experiments in which drugs were incorporated into carrageenin and the cotton pellets for inducing inflammation. The anti-inflammatory action of NaC is not mediated through release of steroids from the adrenal cortex or inhibition of the biosynthesis of prostaglandins from arachidonic acid. The results of the present study support the rationale for the use of powdered rhizome of turmeric (contains 0.6% of curcumin) for conditions of sprain and inflammation.

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References

  1. [1]
    V. Lampe, J. Milobedzka andSt. V. Kostanecki, Ber.43, 2163 (1910) quoted from:P.J. Roughley andD.A. Whiting,Experiments in the biosynthesis of curcumin, J. Chem. Soc.20, 2379–2388 (1973).Google Scholar
  2. [2]
    Wealth of India. InRaw Materials, p. 402. CSIR, New Delhi 1950.Google Scholar
  3. [3]
    E. Bacon,Health protection branch regulation of food additives, Can. Pharm. J.112, 340–344 (1979).Google Scholar
  4. [4]
    D.M. Marmion, Colorants exempt from certification. InHandbook of US Colorants for Food, Drugs and Cosmetics, pp. 86–87. John Wiley and Sons, New York 1979.Google Scholar
  5. [5]
    R.N. Chopra, I.C. Chopra, K.L. Honda andL.D. Kapur. InIndigenous Drugs of India, 2nd edn, pp. 325–327. U.N. Dhar and Sons Pvt. Ltd., Calcutta 1958.Google Scholar
  6. [6]
    R.B. Arora, N. Basu, V. Kapoor andA.P. Jain,Anti-inflammatory studies on Curcuma longa (turmeric), Ind. J. Med. Res.59, 1289–1295 (1971).Google Scholar
  7. [7]
    D. Chandra andS.S. Gupta,Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa, Ind. J. Med. Res.60, 138–142 (1972).Google Scholar
  8. [8]
    N. Ghatak andN. Basu,Sodium curcuminate as an effective anti-inflammatory agent, Ind. J. Expt. Biol.10, 235–236 (1972).Google Scholar
  9. [9]
    R.C. Srimal andB.N. Dhawan,Pharmacology of diferyloyl methane (curcumin) a non-steroidal antiinflammatory agent, J. Pharm. Pharmacol.25, 447–452 (1972).Google Scholar
  10. [10]
    L. Reisterer andR. Jaques,The local anti-inflammatory action of non-steroidal compounds on the paw edema caused by kaolin in the rat, Helv. Physiol. Pharmacol. Acta25, 156–159 (1967).PubMedGoogle Scholar
  11. [11]
    R.W. Shanahan,Local activity of anti-inflammatory and irritant agents on rat paw edema induced by carrageenin, Arch. Int. Pharmacodyn. Ther.175, 186–192 (1968).PubMedGoogle Scholar
  12. [12]
    C.A. Winter, E.A. Risley andC.W. Nuss,Carrageenin induced edema in hind paw of the rat as an assay for anti-inflammatory drugs, Proc. Soc. Exp. Biol. Med.111, 544–547 (1962).Google Scholar
  13. [13]
    C.G. Van Arman, A.J. Begany, L.M. Miller andH.H. Pless,Some details of the inflammations caused by yeast and carrageenan (with appendix on kinetics of the reaction), J. Pharmacol. Exp. Ther.150, 328–334 (1965).Google Scholar
  14. [14]
    P.F. D'Arcy, E.M. Howard, P.W. Muggleton andS.B. Townsend,The anti-inflammatory action of griseofulvin in experimental animals,J. Pharm. Pharmacol. 12, 659–665 (1960).PubMedGoogle Scholar
  15. [15]
    G. Dispasquale andA. Meli,Effect of body weight changes on the formation of cotton pellet induced granuloma, J. Pharm. Pharmacol.17, 379–382 (1965).PubMedGoogle Scholar
  16. [16]
    D. Matingly,A simple fluorometric method for the estimation of the free II-hydroxy corticosteroids in human plasma, J. Clin. Path.15, 374–379 (1962).PubMedGoogle Scholar
  17. [17]
    P. Schultzer,Mortality of adrenalectomized young rats with improved technique of operation and after a period of treatment with corticol hormone, J. Physiol.84, 70–84 (1935).Google Scholar
  18. [18]
    L.B. Witkin, C.F. Heubner, F. Galdi, E. O'Keefe, P. Spitaletta andA.J. Plummer,Pharmacology of 2-amino-indane hydrochloride (SU-8629): a potent non-narcotic analgesic, J. Pharmacol. Exp. Ther.133, 400–408 (1961).PubMedGoogle Scholar
  19. [19]
    C.V. Winder, J. Wax, B. Serrano, L. Scotti, S.P. Stackhouse, R.H. Wheelock,Pharmacological studies of 1,2-dimethyl-3-phenyl-3-propionoxy pyrolidine (CI-427), an analgesic agent, J. Pharmacol. Exp. Ther.133, 117–128 (1961).PubMedGoogle Scholar
  20. [20]
    G.V.R. Born,Aggregation of blood platelets by adenosine diphosphate and its reversal,Nature 194, 927–929 (1962).PubMedGoogle Scholar
  21. [21]
    G.W. Snedecor andW.C. Cochran, In Statistical Methods, p. 26. Oxford and IBM Publishing, New Delhi 1967.Google Scholar
  22. [22]
    J.R. Vane,Prostaglandins and aspirin-like drugs, Hosp. Prac.7, 61–71 (1972).Google Scholar
  23. [23]
    D.C. Atkinson andR. Hicks,The anti-inflammatory activity of irritants, Agents and Actions5, 239–249 (1975).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • A. Mukhopadhyay
    • 1
  • N. Basu
    • 1
  • N. Ghatak
    • 1
  • P. K. Gujral
    • 1
  1. 1.Department of PharmacologyAll-India Institute of Medical SciencesNew DelhiIndia

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