, Volume 36, Issue 5, pp 584–585 | Cite as

Effect of cyproheptadine on the octopamine-induced responses in the mammalian central nervous system

  • W. P. C. Dao
  • R. J. Walker


Extracellular recordings have been made from rat thalamic neurones anaesthetized with urethane, 1.5–2 g/kg i.p. Iontophoretically applied octopamine excited certain thalamic neurones in the ventral basal complex while inhibiting others. Both effects were reversibly antagonized by iontophoretically applied cyproheptadine without affecting responses to noradrenaline and dopamine.


Nervous System Central Nervous System Dopamine Noradrenaline Urethane 
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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • W. P. C. Dao
    • 1
  • R. J. Walker
    • 1
  1. 1.School of Biochemical and Physiological SciencesUniversity of SouthamptonSouthampson(England)

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