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, Volume 12, Issue 1–2, pp 183–185 | Cite as

Isolation and properties of mast cells from the small bowel lamina propria of the rat

  • F. L. Pearce
  • A. D. Befus
  • J. Bienenstock
Histamine and Kinins Histamine and Mast Cells

Abstract

A method is described for the isolation of mast cells from the mucosa of the small intestine of rats infected with the nematodeNippostrongylus brasiliensis. The cells release histamine on challenge with IgE-directed ligands and calcium ionophores but, in contrast to rat peritoneal mast cells, are refractory to the action of basic secretagogues. The mucosal and peritoneal cells also differ markedly in their sensitivity to particular anti-allergic drugs. These results further emphasize the functional heterogeneity of mast cells from different sources.

Keywords

Calcium Mast Cell Histamine Small Intestine Small Bowel 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • F. L. Pearce
    • 1
  • A. D. Befus
    • 2
  • J. Bienenstock
    • 2
  1. 1.Department of ChemistryUniversity College LondonLondonEngland
  2. 2.The Host Resistance Programme, Department of PathologyMcMaster UniversityHamiltonCanada

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