Agents and Actions

, Volume 25, Issue 3–4, pp 314–320 | Cite as

Histamine release from nasal mucosal mast cells in patients with chronic hypertrophic non-allergic rhinitis, after parasympathetic nerve stimulation

  • L. Rucci
  • E. Masini
  • M. B. Cirri Borghi
  • E. Giannella
  • P. F. Mannaioni
Article
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Abstract

The vidian nerve provides the main parasympathetic nerve supply to nasal respiratory and maxillary sinus mucosa, and its electrical stimulation causes apparent secretory and vasodilatatory effects in animals.

The present investigation was carried out in 8 patients with chronic hypertrophic non-allergic rhinitis (C.H.N.A.R.) undergoing therapeutic vidian nerve resection. The vidian nerve was electrically stimulated before the resection. Samples were taken from nasal sinus mucosa for histamine determination and microscopical observation before and after the stimulation period. Vidian nerve stimulation causes a significant decrease in histamine content and mast cell density in the mucosa sample, differentially influenced by eserine and atropine pretreatment.

Keywords

Mast Cell Histamine Nerve Stimulation Nasal Sinus Maxillary Sinus 
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References

  1. [1]
    K. S. Kim and P. A. Shore,Mechanism of action of reserpin and insulin on gastric amines and gastric acid secretion and the effect of monoamine oxidase inhibition. J. Pharmac. exp. Ther.141, 321–325 (1963).Google Scholar
  2. [2]
    P. A. Shore,Release of histamine from stomach by vagus-stimulating drugs: association with gastric acid secretion. Fedn. Proc.24, 1322–1325 (1965).Google Scholar
  3. [3]
    G. Kahlson, E. Rosengren and R. Thurnberg,Accelerated mobilization and formation of histamine in the gastric mucosa evoked by vagal excitation. J. Physiol.190, 455–463 (1967).PubMedGoogle Scholar
  4. [4]
    E. Werle and W. Lorenz,Speicheldrüsensekretion nach pilocarpin, histamin und kininen. Archs. Int. Pharmacodyn. Ther.161, 477–488 (1966).Google Scholar
  5. [5]
    F. Erjavec, M. A. Beaven and B. B. Brodie,Uptake and release of [ 3H]-histamine in cat sub-maxillary gland. Fedn. Proc.26, 237–240 (1967).Google Scholar
  6. [6]
    W. Lorenz, G. Haubensak, M. Hutzel and E. WerleHistaminliberierung in G1. Sumaxillaris and Pankreas durch parasympathicomimetic, peptidhormone, histamin, und mepyramin. Naunyn-Schmiederberg's Arch. exp. Path. Pharmak.260, 416–437 (1968).Google Scholar
  7. [7]
    W. Lorenz, A. Huhndt, J. Kusche, H. Barth, G. Haubensack, M. Hutzel, A. Schmal, M. Gerant, A. Wächter, E. Matejka, H. Hahn and E. WerleHistamine and salivary secretion. In:Histamine. (Ed. C. Maslinski), pp. 187–200 Strondsburg, Dowden, Hutchinson and Ross, 1973.Google Scholar
  8. [8]
    F. Erjavec,The Physiological Fuction of Mast Cell Histamine. Abstracts, 7th International Congress of Pharmacology. Paris, Oxford, Pergamon, 1973.Google Scholar
  9. [9]
    W. T. Ulmer,Effect of exogenous and endogenous histamine on the respiratory system. Symposium on Histamine and Antihistamines in Anaesthesia and Surgery. Munich, June 3–5, (1981).Google Scholar
  10. [10]
    M. Kaliner, R. P. Orange and K. F. Austen,Immunological release of histamine and slow reacting substance of anaphylaxis from human lung IV.Enhancement by cholinergic and alpha adrenergic stimulation. J. exp. Med.136, 556–567 (1972).PubMedGoogle Scholar
  11. [11]
    M. Kaliner, S. J. Wassermann and K. F. Austen,Immunological release of chemical mediators from human nasal polyps. New Engl. J. Med.289, 277–281 (1973).PubMedGoogle Scholar
  12. [12]
    C. H. Cho and C. W. Ogle,Cholinergic mediated gastric mast cell degranulation with subsequent histamine H 1- and H2-receptor activation in stress ulceration in rats. Eur. J. Pharmac.55, 23–33 (1979).Google Scholar
  13. [13]
    T. J. Sullivan, K. L. Parker, W. Stenson and C. W. Parker,Modulation of cyclic AMP in purified rat mast cells. I. Responses to pharmacologic, metabolic and physical stimuli. J. Immun.114, 1473–1479 (1975).PubMedGoogle Scholar
  14. [14]
    W. Schmutzler, G. Poblete-Freundt, K. Rauch and W. Schönfeld,Response to immunological or cholinergic stimulation of isolated mast cells from man, guinea-pig and rat. CIA Symposium, New Orleans, In Monograph on Allergy, vol. 14, pp. 49–56. S. Karger, Basel, 1978.Google Scholar
  15. [15]
    E. Masini, R. Fantozzi, A. Conti, P. Blandina, S. Brunelleschi and P. F. Mannaioni,Immunological modulation of cholinergic histamine release in isolated rat mast cells. Agents and Actions16, 152–155 (1985).PubMedGoogle Scholar
  16. [16]
    J. Heymanns, H. Behredt and W. Schmutzler,Comparative studies of mast cells from normal (non-immunized) and actively sensitized dogs. Agents and Actions12, 192–198 (1982).PubMedGoogle Scholar
  17. [17]
    T. Bani Sacchi, M. Barattini, S. Bianchi, P. Blandini, S. Brunelleschi, R. Fantozzi, P. F. Mannaioni and E. Masini,The release of histamine by parasympathetic stimulation in guinea-pig auricle and rat ileum. J. Physiol.371, 29–43. (1986).PubMedGoogle Scholar
  18. [18]
    H. Heine and F. J. Forster,Relationship between mast cells and preterminal nerve fibres. Z. mokrosk. anat Forsch.89, 934–937 (1975).Google Scholar
  19. [19]
    N. Jabonero,Die plexiforme Synapse auf Distans und die Bedentung der sorgenannter interkalären Zellen. Acta Neuroveg.19, 276–303 (1959).Google Scholar
  20. [20]
    W. Stach, R. Weiss and R. Radke, Licht- und elektronenmikroskopische Untersuchungen über die Nervengeflechte der Magenschleimhaut und deren Beziehungen zu Beleg-und Mastzellen, Dt. Z. Verdan-Stoffwechselkr.35, (5), 205–218 (1975).Google Scholar
  21. [21]
    L. Wiesner-Menzel, B. Schulz, F. Vakilzadeh and B. M. Czarnetzki,Electron microscopical evidence for a direct contact between nerve fibres and mast cells. Acta Dermatovener (Stockholm)61, 465–469 (1981).Google Scholar
  22. [22]
    B. Newson, A. Dahlstrom, L. Enerbach and H. Ahlman,Suggestive evidence for a direct innervation of mucosal mast cells. Neuroscince10, 565–570 (1983).Google Scholar
  23. [23]
    P. H. Golding-Wood,Observations on petrosal and vidian neurectomy in chronic vasomotor rhinitis. J. of Laryng,75, 232–247 (1961).Google Scholar
  24. [24]
    A. Anggard,The effects of parasympathetic nerve stimulation on the microcirculation and secretion in the nasal mucosa of the cat. Acta Otolaryng.78, 98–105 (1974).PubMedGoogle Scholar
  25. [25]
    L. Rucci, B. Cirri Borghi, T. Pantaleo and A. Cagnoli,The effect of vidian nerve stimulation on the nasal and maxillary sinus mucosa. I. Laryng. and Otol.98, 596–607 (1984).Google Scholar
  26. [26]
    E. Masini, L. Rucci, M. B. Cirri Borghi, E. Giannella and P. F. Mannaioni,Stimulation and resection of vidian nerve in patients with chronic hypertonic non-allergic rhinitis: effect on histamine content in nasal mucosa. Agents and Actions18, 251–253 (1986).PubMedGoogle Scholar
  27. [27]
    J. Prades,Microchirurgia endonasal de la fosa pterigomaxilar y del meato medio. Salvat Ed., Barcelona 1980.Google Scholar
  28. [28]
    A. Anggard,Parasympathetic influence on the nasal vasomotor oscillations in the cat. Acta Otolaryng.83, 22–24 (1977).PubMedGoogle Scholar
  29. [29]
    J. H. Luft,Improvements in epoxy resin enbedding methods, J. Bioph. Biochem. Cytol. Suppl.9, 409 (1961).Google Scholar
  30. [30]
    P. A. Shore, A. Burkhalter and V. H. Cohn,A method for the fluorimetric assay of histamine in tissue. J. Pharmacol. exp. Ther.127, 182–186 (1959).PubMedGoogle Scholar
  31. [31]
    W. Lorenz, H. J. Reimann, H. Barth, J. Kusche, R. Meyer, A. Doenicke and M. Hutzel,A. sensitive ans specific method for the determination of histamine in human whole blood and plasma. Hoppe-Seyler's Z. für Physiologische Chemie353, 911–920 (1972).Google Scholar
  32. [32]
    R. Eccles and H. Wilson,The parasympathetic secretory nerves of the nose in the cat. J. Physiol.230, 213–223 (1973).PubMedGoogle Scholar
  33. [33]
    J. M. Lundberg, A. Anggard, P. Enson, J. Fahrenkrug and T. Hokfelt,Vasoactive intestinal polypeptide and cholinergic mechanism in cat nasal mucosa: studies on choline acetyltransferase and release of vasoactive intestinal polypeptide. Proc. Natl. Acad. Sci. USA78, 5255–5259 (1981).PubMedGoogle Scholar
  34. [34]
    R. Fantozzi, E. Masini, P. Plandina, P. F. Mannaioni and T. Bani Sacchi,Release of histamine from rat mast cells by acetylcholine. Nature273, 473–474 (1978).PubMedGoogle Scholar
  35. [35]
    W. Kazimierczak and B. Diamant,Mechanism of histamine release in anaphylactic and anaphylactoid reactions. Prog. Allergy24, 295–365 (1978).PubMedGoogle Scholar
  36. [36]
    J. C. Foreman,The pharmacological control of immediate hypersensitivity, Ann. Rev. Pharmacol. Toxicol.21, 63–81 (1981).Google Scholar
  37. [37]
    W. Kazimierczak, B. Adamas and Cz. Máslínski,Failure of acetylcholine to release histamine from rat mast cells. Agents and Actions10, 1–3 (1980).PubMedGoogle Scholar
  38. [38]
    C. J. Hanna, M. E. Johnston and R. R. Schellenberg,Evaluation of the action of cholinergic agonists and cyclic guanosine monophosphate (c'GMP) on histamine release from purified rat mast cells. Immunopharmacology3, 233–240 (1981).PubMedGoogle Scholar
  39. [39]
    B. H. Selbekk, O. Flaten and L. E. Hanssen,The in vitro effect of neurotensin on human Jejunal mast cells. Scand. J. Gastroent.15, 457–460 (1980).PubMedGoogle Scholar
  40. [40]
    W. Piotrowski, M. A. B. Devoy, C. C. Jordan and J. C. Foreman,The substances P receptor on rat mast cells and in human skin. Agents and Actions14, 420–424 (1984).PubMedGoogle Scholar
  41. [41]
    P. B. Canwenberge,The role of chemical mediators and neurotransmitters in rhinopathy of allergic and non-allergic origin. 2o Corso Tecnico Pratico Allergico-Immunologico in O.R.L., p. 26, 1985.Google Scholar
  42. [42]
    J. A. Kiernam,Effect of known and suspected neurotransmitter substances and of some nucleotides on isolated mast cells. Experentia28, 653–655 (1972).Google Scholar
  43. [43]
    M. G. Harries, P. S. O'Brien Burge and J. Pepys,Histamine release in experimentally induced asthma and urticaria. InThe Mast Cell: its Role in Health and Disease. (Eds. J. Pepys and A. M. Edwards, pp. 193–196, Pitman Medical Publishing, Tunbridge Wells, 1979.Google Scholar

Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • L. Rucci
    • 1
  • E. Masini
    • 2
  • M. B. Cirri Borghi
    • 3
  • E. Giannella
    • 2
  • P. F. Mannaioni
    • 2
  1. 1.Institute of Otorhinolaryngology, Section of Histology “E. Allara”Florence UniversityFlorenceItaly
  2. 2.Department of Preclinical and Clinical Pharmacology “M. Aiazzi-Mancini”, Section of Histology “E. Allara”Florence UniversityFlorenceItaly
  3. 3.Department of Human Anatomy and Histology, Section of Histology “E. Alara”Florence UniversityFlorenceItaly

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