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, Volume 25, Issue 3–4, pp 228–230 | Cite as

Neurogenic inflammation in the skin of the rabbit

  • B. Lynn
  • J. Shakhanbeh
Article

Abstract

A flare-like spread of vasodilatation can be demonstrated in the limb skin of the anaesthetised rabbit using laser doppler flowmetry. Spread of dilatation from a small mechanical injury (nicking the skin) extends 5–10 mm. The size and time course of the dilatation are as expected from the low frequency C-nociceptor firing that occurs in response to similar nearby injury. Since C-nociceptors cause significant vasodilator responses at frequencies less than 1 Hz, it is proposed that they may often have a proinflammatory action without producing any reflex or sensory effects.

Keywords

Mechanical Injury Sensory Effect Laser Doppler Flowmetry Vasodilator Response Neurogenic Inflammation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • B. Lynn
    • 1
  • J. Shakhanbeh
    • 1
  1. 1.Department of PhysiologyUniversity College LondonLondonUK

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