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Comparative in vitro activity of biapenem, a new carbapenem antibiotic

  • A. M. Clarke
  • S. J. V. Zemcov
New Antimicrobial Agents

Abstract

Biapenem is a new carbapenem antibiotic with high stability to human renal dehydropeptidase I. Its in vitro activity was compared with that of imipenem, meropenem, ceftazidime, ceftriaxone, piperacillin and gentamicin against a total of 650 recent clinical isolates. MICs were determined by a standard agar dilution procedure and all isolates were tested at two inocula (104 and 106 cfu). Biapenem inhibited 90 % of isolates ofEscherichia coli, Klebsiella spp.,Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia stuartii, Enterobacter spp.,Citrobacter freundii, Serratia marcescens, Salmonella typhi, Shigella sonnei andYersinia enterocolitica at ≤ 2 mg/l and was as active as or two- to four-fold more active than imipenem against all these species, with the exception ofSerratia marcescens, against which imipenem was two-fold more active. Biapenem was two-fold more active than imipenem againstPseudomonas aeruginosa (MIC90 4 mg/l) and had activity similar to that of imipenem against theBacteroides fragilis group (MIC90 0.5 mg/l) but was two-fold less active than imipenem against methicillin-susceptibleStaphylococcus aureus (MIC90 0.06 mg/l) and was, like imipenem, inactive against methicillin-resistantStaphylococcus aureus.

Keywords

Gentamicin Clinical Isolate Ceftriaxone Ceftazidime Imipenem 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1993

Authors and Affiliations

  • A. M. Clarke
    • 1
  • S. J. V. Zemcov
    • 1
  1. 1.Division of Medical MicrobiologySt. Paul's HospitalVancouverCanada

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