Enteral nutrition as a risk factor for nosocomial pneumonia

  • S. K. Pingleton
Current Topic: Editorial

Abstract

Nutritional support of critically ill patients in the intensive care unit is important, since adverse effects of malnutrition are multiple and common. Nutrition via the enteral or gastrointestinal tract is often preferred over central venous or total parenteral nutrition as the initial choice of nutritional therapy due to its relative ease of administration, lower cost and infrequent association with severe complications. Recent data suggest that nosocomial pneumonia, a severe and ominous complication of critical illness, is related to gastric colonization secondary to alkalinization of stomach contents by antacids and H2-antagonists. Nosocomial pneumonia may also be related to enteral nutrition. Gastric microbial growth increases after the onset of enteral nutrition. Gastric organisms can be transmitted to the trachea and result in tracheal colonization and nosocomial pneumonia. Gastric to tracheal transmission of organisms is probably related to pulmonary aspiration. Several factors are important in pulmonary aspiration, including nasogastric tube size, method of nutrient delivery, patient position, and gastric and intestinal motility. Enteral nutrition must be considered in both the evaluation of mechanisms of nosocomial pneumonia and the strategies of prophylaxis.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Driver, A. G., McAlevy, M. T., Smith, J. L. Nutritional assessment of patients with chronic obstructive pulmonary disease and acute respiratory failure. Chest 1982, 82: 568–571.PubMedGoogle Scholar
  2. 2.
    Pingleton, S. K., Eulberg, M. Nutritional analysis of acute respiratory failure. Chest 1983, 84: 343.Google Scholar
  3. 3.
    Rochester, D. F., Esau, S. A. Malnutrition and the respiratory system. Chest 1984, 85: 411–415.PubMedGoogle Scholar
  4. 4.
    Apelgren, K. N., Wilmore, D. W. Nutritional care of the critically ill patient. Surgery Clinics of North America 1983, 63: 497–507.Google Scholar
  5. 5.
    Martin, T. R. Relationship between malnutrition and lung functions. Clinics in Chest Medicine 1987, 3: 359–373.Google Scholar
  6. 6.
    Thomas, L., Gerald, M., Malquarti, V. Etat nutritional des malades admis en reanimation: relation avec la mortalite. Nouvelle Presse Medicine 1979, 8: 409–414.Google Scholar
  7. 7.
    Bassili, H. R., Dietel, M. Effect of nutritional support on weaning patients off mechanical ventilation. Journal of Parenteral and Enteral Nutrition 1981, 5: 161–163.PubMedGoogle Scholar
  8. 8.
    Lorca, L., Greenbaum, D. M. Effectiveness of intensive nutritional regimens in patients who fail to wean from mechanical ventilation. Critical Care Medicine 1982, 10: 297–300.PubMedGoogle Scholar
  9. 9.
    Askanazi, J., Hensle, T., Starker, P. Effects of immediate postoperative nutritional support on length of hospitalization. Annals of Surgery 1986, 203: 236–239.PubMedGoogle Scholar
  10. 10.
    Starker, P. M., LaSala, P. A., Askanazi, J. The influence of preoperative total parenteral nutrition upon morbidity and mortality. Surgery Gynecology and Obstetrics 1986, 162: 569–574.Google Scholar
  11. 11.
    Heymsfied, S. B., Bethel, R. A., Ansley, J. D., Nixon, D. W., Rudman, D. Enteral hyperalimentation. Annals of Internal Medicine 1979, 90: 63–71.PubMedGoogle Scholar
  12. 12.
    Szeluga, Stuart, R. K., Brookmeyer, R., Utermohlen, Santos, G. W. Nutritional support of bone marrow transplant recipients: a prospective randomized clinical trial comparing total parental nutrition to an enteral feeding program. Cancer Research 1987, 47: 3309–3312.PubMedGoogle Scholar
  13. 13.
    Johnson, L. R., Copeland, E. M., Dudrick, S. J. Structural and hormonal alterations in the gastrointestinal tract of parenterally fed rats. Gastroenterology 1975, 68: 1177–1183.PubMedGoogle Scholar
  14. 14.
    Saito, H., Trocki, O., Alexander, J. W., Kopcha, R., Heyd, T., Joffe, S. N. The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion, and gut mucosal integrity after burn injury. Journal of Parenteral and Enteral Nutrition 1987; 11: 1–7.PubMedGoogle Scholar
  15. 15.
    Alverdy, J., Chi, H. S., Sheldon, G. F. The effect of parenteral nutrition on gastrointestinal immunity: the importance of enteral stimulation. Annals of Surgery 1985, 202: 681–684.PubMedGoogle Scholar
  16. 16.
    Deitch, E. A., Maejima, K., Berg, R. Effect of oral antibiotics and bacterial overgrowth on the translocation of the GI tract miroflora in burned rats. Journal of Trauma 1985, 25: 385–392.PubMedGoogle Scholar
  17. 17.
    Fletcher, J. P., Little, J. M. A comparison of parental nutrition and early post-operative enteral feeding on the nitrogen balance after major surgery. Surgery 1986, 100: 21–24.PubMedGoogle Scholar
  18. 18.
    Choctaw, W. T., Fujita, C., Zawacki, B. E. Prevention of upper gastrointestinal bleeding in burn patients. Archives of Surgery 1980, 115: 1073–1076.PubMedGoogle Scholar
  19. 19.
    Solem, L. D., Strate, R. G., Fischer, R. P. Antacid therapy and nutritional supplementation in the prevention of Curling's ulcer. Surgery, Gynecology & Obstetrics 1979, 148: 367–370.Google Scholar
  20. 20.
    Pingleton, S. K., Hadizma, S. Enteral alimentation and gastrointestinal bleeding in mechanically ventilated patients. Critical Care Medicine 1983, 11: 13–16.PubMedGoogle Scholar
  21. 21.
    Valentine, R. J., Turner, W. W., Borman, D. R., Weigelt, J. A. Does nasoenteral feeding afford adequate gastroduodenal stress prophylaxis? Critical Care Medicine 1986, 14: 599–601.PubMedGoogle Scholar
  22. 22.
    Rigaud, D., Chastre, J., Accary, J. P., Bonfils, S., Hance, A. J. Intragastric pH profile during acute respiratory failure in patients with chronic obstructive pulmonary disease. Chest 1986, 90: 58–62.PubMedGoogle Scholar
  23. 23.
    Lally, K. P., Andrassy, R. J., Foster, J. E., Wilz, W. R., Hosbein, D. P., Torma, M. J. Evaluation of various nutritional supplements in the prevention of stress-induced gastric ulcers in the rat. Surgery, Gynecology & Obstetrics 1984, 158: 124–128.Google Scholar
  24. 24.
    Menguy, R., Masters, Y. F. Gastric mucosal energy metabolism and “stress ulcerations”. Annals of Surgery 1984, 180: 538–542.Google Scholar
  25. 25.
    Ephgrave, K. S., Horton, J. W. Comparison of approaches to stress ulcer prophylaxis in hemorrhagic shock. Journal Surgical Research 1987, 42: 52–61.CrossRefGoogle Scholar
  26. 26.
    Nakagawa, K., Okada, A., Kawashima, Y. Acute gastric mucosal lesions: a new experimental model and effect of parenteral nutritional. Journal of Parenteral and Enteral Nutrition 1985, 9: 571–582.PubMedGoogle Scholar
  27. 27.
    Atherton, S. T., White, D. J. Stomach as source of bacteria colonizing respiratory tract during artificial ventilation. Lancet 1978, ii: 968–969.CrossRefGoogle Scholar
  28. 28.
    Hillman, K. M., Riodan, T., O'Farrell, S. M., Tabaqchali, S. Colonization of the gastric contents in critically ill patients. Critical Care Medicine 1982, 109: 444–447.Google Scholar
  29. 29.
    Du Moulin, G. C., Hedley-White, J., Paterson, D. S., Hedley-White, J., Lisbon, A. Aspiration of gastric bacteria in antacid-treated patients: a frequent cause of post-operative colonisation of the airway. Lancet 1982, i: 242–245.CrossRefGoogle Scholar
  30. 30.
    Daschner, F., Kappstein, I., Reuschenbach, K., Pfisterer, J., Krieg, N., Vogel, W. Stress ulcer prophylaxis and ventilation pneumonia: prevention by antibacterial cyto-protective agents. Infection Control and Hospital Epidemiology 1988, 9: 59–65.PubMedGoogle Scholar
  31. 31.
    Pingleton, S. K., Hinthorn, D., Lui, C. Enteral nutrition in patients receiving mechanical ventilation. American Journal of Medicine 1986; 80: 827–832.CrossRefPubMedGoogle Scholar
  32. 32.
    Drasar, B. S., Shiner, M. Studies on the intestinal flora. II: Bacterial flora of the small intestine in patients with gastrointestinal disorders. Gut 1969, 10: 812–819.PubMedGoogle Scholar
  33. 33.
    Wynne, J. W., Modell, J. H. Respiratory aspiration of stomach contents. Annals of Internal Medicine 1977, 87: 466–474.PubMedGoogle Scholar
  34. 34.
    Spray, S. B., Zuidema, G. D., Cameron, J. L. Aspiration pneumonia: incidence of aspiration with endotracheal tubes. American Journal of Surgery 1979, 131: 701–703.CrossRefGoogle Scholar
  35. 35.
    Winterbauer, R. H., Durning, R. B., Barron, E., McFadden, M. C. Aspirated nasogastric feeding solution detected by glucose strips. Annals of Internal Medicine 1981, 95: 67–68.PubMedGoogle Scholar
  36. 36.
    Metheny, N. A., Eisenberg, P., Spies, M. Aspiration pneumonia in patients fed through nasoenteral tubes. Heart and Lung 1986; 15: 256–261.PubMedGoogle Scholar
  37. 37.
    Treloar, D. M., Stechmiller, J. Pulmonary aspiration in tube-fed patients with artificial airways. Heart and Lung 1984, 13: 667–671.PubMedGoogle Scholar
  38. 38.
    Meer, J. A. Inadvertent dislodgement of nasoenteral feeding tubes: incidence and prevention. Journal of Parenteral and Enteral Nutrition 1987, 11: 187–189.PubMedGoogle Scholar
  39. 39.
    Silk, D. B. A., Rees, R. G., Keohane, P. P., Attrili, H. Clinical efficacy and design changes of “fine bore” nasogastric feeding tubes: a seven-year experience involving 809 intubations in 403 patients. Journal of Parenteral and Enteral Nutrition 1987, 11: 378–383.PubMedGoogle Scholar
  40. 40.
    Boscoe, M. J., Rosin, M. D. Fine bore enteral feeding and pulmonary aspiration. British Medical Journal 1984, 289: 1421–1422.PubMedGoogle Scholar
  41. 41.
    Cole, M. J., Smith, J. T., Molnar, C., Shaffer, E. A. Aspiration after percutaneous gastrostomy: assessment by Tc-99m labeling of the enteral feed. Journal of Clinical Gastroenterology 1987, 9: 90–95.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1989

Authors and Affiliations

  • S. K. Pingleton
    • 1
  1. 1.University of Kansas Medical CenterKansas CityUSA

Personalised recommendations