Experientia

, Volume 38, Issue 6, pp 680–681 | Cite as

Thymic control of the polyploidization of hepatocytes during aging

  • C. Pieri
  • C. Giuli
  • C. Bertoni-Freddari
  • L. Piantanelli
  • I. Zs. Nagy
Article

Summary

Relative DNA-contents of hepatocyte nuclei have been determined in young, old, and thymus-grafted old mice. There is an age-dependent increase in the occurrence of tetraploid nuclei, which is in agreement with previous data regarding the nuclear volume of hepatocytes. The neonatal thymus grafted into old recipients decreased the percentage of tetraploid cells to a statistically significant extent.

Keywords

Significant Extent Nuclear Volume Tetraploid Cell Hepatocyte Nucleus Tetraploid Nucleus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Literature

  1. 1.
    H. Plenck, Arb. zool. Inst. Univ. Wien19, 247 (1911).Google Scholar
  2. 2.
    C. Pieri, C. Giuli, M. Del Moro and L. Piantanelli, Mech. Age Dev.13, 275 (1980).Google Scholar
  3. 3.
    H. Tauchi, Nagoya J. med. Sci.24, 97 (1961).Google Scholar
  4. 4.
    A. O. Pogo, B. G. T. Pogo and J. R. C. Funes, Exp. Cell Res.20, 208 (1960).Google Scholar
  5. 5.
    R. C. Guimares, Braz. Resquisas Med. Biol.4, 169 (1971).Google Scholar
  6. 6.
    L. Ranek, Acta cytol.20, 151 (1976).Google Scholar
  7. 7.
    A. Shima and T. Sugahara, Exp. Geront.11, 193 (1976).Google Scholar
  8. 8.
    S. Fujita, J. comp. Neurol.155, 195 (1974).Google Scholar
  9. 9.
    L. Piantanelli, A. Basso, M. Muzzioli and N. Fabris, Mech. Age Dev.7, 171 (1978).Google Scholar
  10. 10.
    L. Piantanelli, P. Fattoretti and C. Viticchi, Mech. Age Dev.14, 155 (1980).Google Scholar
  11. 11.
    F. J. Swartz, Exp. Cell Res.48, 557 (1967).Google Scholar
  12. 12.
    C. Nadal and F. Zajdela Exp. Cell Res.42, 117 (1966).Google Scholar
  13. 13.
    D. Amici, G. L. Gianfranceschi, G. Marsili and L. Michetti, Experientia30, 633 (1974).Google Scholar
  14. 14.
    G. L. Gianfranceschi, D. Amici and L. Guglielmi, Biochim. biophys. Acta414, 9, (1975).Google Scholar
  15. 15.
    G. L. Gianfranceschi, D. Amici and L. Guglielmi, Molec. Biol. Rep.3, 55 (1976).Google Scholar
  16. 16.
    G. L. Gianfranceschi, D. Amici and L. Guglielmi, Nature262, 622 (1976).Google Scholar
  17. 17.
    C. Giuli, C. Pieri, L. Piantanelli and N. Fabris, Mech. Age Dev.13, 265 (1980).Google Scholar
  18. 18.
    L. Piantanelli and N. Fabris, in: Genetic Effects on Aging, p. 315. Ed. D. E. Harrison. The National Foundation, 1978.Google Scholar
  19. 19.
    N. Fabris and L. Piantanelli, in: Hormones and Aging. Eds R. Adelman and Roth. CRC Press, Palm Beach 1981; in press.Google Scholar

Copyright information

© Birkhäuser-Verlag 1982

Authors and Affiliations

  • C. Pieri
    • 1
    • 2
  • C. Giuli
    • 1
    • 2
  • C. Bertoni-Freddari
    • 1
    • 2
  • L. Piantanelli
    • 1
    • 2
  • I. Zs. Nagy
    • 1
    • 2
  1. 1.F. Verzar International Laboratory for Experimental Gerontology (VILEG), Italian Section, Center of Cytology, and Center of BiochemistryI.N.R.C.A.AnconaItaly
  2. 2.VILEG, Hungarian SectionUniversity Medical SchoolDebrecenHungary

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