Experientia

, Volume 35, Issue 10, pp 1367–1368

The principal toxin ofDelphinium brownii Rydb., and its mode of action

  • V. Nambi Aiyar
  • M. H. Benn
  • T. Hanna
  • J. Jacyno
  • S. H. Roth
  • J. L. Wilkens
Specialia

Summary

Examination ofD. brownii, a stock-poison of Western Canada, revealed that the principal toxin was methyllycaconitine: a potent neuromuscular blocking agent which appears to act competitively at nicotinic receptors.

References

  1. 2.
    R.F. Keeler, Llyodia38, 56 (1975).Google Scholar
  2. 3.
    V.N. Aiyar, M. Benn, Y.Y. Huang, J.M. Jacyno and A.J. Jones, Phytochemistry17, 1453 (1978).Google Scholar
  3. 4.
    F.N. Dzhakhangirov, I. Khamdamov and F.S. Sadritdinov, Dokl. Akad. Nauk. Uzbek. S.S.R., 32, (1976); Chem. Abstr.85, 103953x (1976).Google Scholar
  4. 5.
    I. Khamdamov, F.N. Dzhakhangirov and F.S. Sadritdinov, Dokl. Akad. Nauk. Uzbek. S.S.R., 37 (1975); Chem. Abstr.84, 84349r (1976).Google Scholar
  5. 6.
    I.A. Gubanov, Planta Medica13, 200 (1965).Google Scholar
  6. 7.
    P.M. Dozortseva, Farm Toxik.22, 34 (1959).Google Scholar
  7. 8.
    M.N. Mats, Rast. Resur.8, 249 (1972); Chem. Abstr.77, 79509 (1972).Google Scholar
  8. 9.
    E. Bülbring, Br. J. Pharmac.1, 38 (1946).Google Scholar
  9. 10.
    W.D.M. Paton, Br. J. Pharmac.12, 119 (1957).Google Scholar
  10. 11.
    W.A. Catterall, J. biol. Chem.252, 8669 (1977).PubMedGoogle Scholar
  11. 12.
    G.N. Moseyeva, A.P. Naumov, Y.A. Negulyaev and E.D. Nosyreva, Biochim. biophys. Acta466, 461 (1977).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • V. Nambi Aiyar
    • 1
    • 2
    • 3
  • M. H. Benn
    • 1
    • 2
    • 3
  • T. Hanna
    • 1
    • 2
    • 3
  • J. Jacyno
    • 1
    • 2
    • 3
  • S. H. Roth
    • 1
    • 2
    • 3
  • J. L. Wilkens
    • 1
    • 2
    • 3
  1. 1.Department of BiologyThe University of CalgaryCalgaryCanada
  2. 2.Department of ChemistryThe University of CalgaryCalgaryCanada
  3. 3.Department of Pharmacology and TherapeuticsThe University of CalgaryCalgaryCanada

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