Effect of meropenem on the intestinal microflora

  • T. Bergan
  • C. E. Nord
  • S. B. Thorsteinsson
New Antimicrobial Agents


Ten healthy volunteers were given 500 mg of meropenem by intravenous infusion over 30 min three times daily for seven days. Stool specimens were collected before, during and after meropenem administration. The numbers of enterobacteria and streptococci decreased during the administration period, while the numbers of enterococci increased. There was a decrease in the numbers of clostridia, bacteroides and gramnegative cocci, while the numbers of gram-positive cocci and rods were not changed by the administration of meropenem. The intestinal flora returned to normal in all volunteers within two weeks after the termination of meropenem administration.


Internal Medicine Healthy Volunteer Intravenous Infusion Meropenem Intestinal Microflora 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1991

Authors and Affiliations

  • T. Bergan
    • 1
    • 2
  • C. E. Nord
    • 3
  • S. B. Thorsteinsson
    • 4
  1. 1.Department of Microbiology, Institute of PharmacyUniversity of OsloOsloNorway
  2. 2.Department of MicrobiologyAker HospitalOsloNorway
  3. 3.Department of Microbiology, Karolinska InstituteHuddinge University HospitalHuddingeSweden
  4. 4.Department of MedicineLandspitalinnReykjavikIceland

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