Maternal vegan diet causing a serious infantile neurological disorder due to vitamin B12 deficiency
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We present a 9-month-old exclusively breastfed baby of a strict vegetarian mother who had excluded all animal proteins from her diet. The patient's symptoms included dystrophy, weakness, muscular atrophy, loss of tendon reflexes, psychomotor regression and haematological abnormalities. Biochemical investigations revealed severe methylmalonic aciduria and homocystinuria in the patient, slight methylmalonic aciduria in the mother and low concentrations of serum vitamin B12 in both patient and mother.
Key wordsVitamin B12 Methylmalonic acid Homocysteine Vegetarian diet
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- 1.Baker S, Jacob E, Rajan K, Swaminathan S (1962) Vitamin B12 deficiency in pregnancy and the puerperium. Br Med J 1: 1658–1661Google Scholar
- 6.Ellenbogen L (1984) Vitamin B12. In: Machlin LJ (ed) Handbook of vitamins. Nutritional, biochemical, and clinical aspects. Dekker, New York, pp 497–547Google Scholar
- 7.Fenton WA, Rosenberg LE (1989) Inherited disorders of cobalamin transport and metabolism. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic basis of inherited disease, 6th edn. McGraw-Hill, New York, pp 2065–2082Google Scholar
- 8.Food and nutrition board (1980) Recommended dietary allowances, 9th edn. National Academy of Sciences, WashingtonGoogle Scholar
- 14.Scott JM, Weir DG (1981) The methyl folate trap. Lancet II:337–340Google Scholar
- 18.Wighton MC, Manson JI, Speed I, Robertson E, Chapman E (1979) Brain damage in infancy and dietary vitamin B12 deficiency. Med J Aust 2:1–3Google Scholar