European Journal of Pediatrics

, Volume 150, Issue 3, pp 179–182 | Cite as

The changes of interleukin-2, tumour necrotic factor and gamma-interferon production among patients with Kawasaki disease

  • C. -Y. Lin
  • C. -C. Lin
  • B. Hwang
  • B. N. Chiang
Infectious Diseases


Included in this study were 43 cases of mucocutaneous lymph node syndrome (MCLS or Kawasaki disease) treated solely with aspirin. Of these, 19 developed coronary aneurysm. Mononuclear cells (MNC) of these MCLS patients were collected weekly and stimulated either with phytohaemagglutinin (PHA) or PHA plus phorbol myristic acetate. The production of interleukin-2 (IL-2), tumour necrotic factor (TNF) and gamma-interferon (IFN-r) was determined. In addition, IL-2, TNF, IFN-r from serial collections of serum samples of these patients were also measured. The results show that serum IL-2 and TNF were detected in the 1st week, reached maximal plateau in the 2nd and 3rd week and decreased 1 month later. The production of IL-2, TNF and IFN-r from MCLS patients' MNC increased from the 1st to the 3rd week, persisted at a high level for 1 month and then decreased. During the 2nd and 3rd weeks, there were significantly higher serum IL-2 levels and IL-2 production in patients with than in patients without coronary lesions. These observations suggest that the serum IL-2 level and IL-2 production during the 2nd week may serve as a predictive parameter for coronary aneurysm formation. It also suggests that the production of TNF, IL-2 and IFN-r from MNC may contribute to the development of vascular injury in acute MCLS.

Key words

Mucotaneous lymph node syndrome Interleukin-2 Tumour necrotic factor Gamma-interferon 









mucocutaneous lymph node syndrom


mononuclear cells




phorbol myristic acetate


tumour necrotic factor


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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • C. -Y. Lin
    • 2
  • C. -C. Lin
    • 1
  • B. Hwang
    • 2
  • B. N. Chiang
    • 1
  1. 1.Department of Medical ResearchVeterans General HospitalTaipeiTaiwan Republic of China
  2. 2.Department of PediatricsVeterans General HospitalTaipeiTaiwan Republic of China

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