Pharmaceutisch Weekblad

, Volume 6, Issue 3, pp 101–104 | Cite as

Formulation of a stable vidarabine phosphate injection

  • M. S. L. Kwee
  • L. M. L. Stolk
Original Articles


An injection fluid with vidarabine phosphate (37.5 mg/ml, pH 7.4) was formulated. After steam sterilization for 20 min at 120°C a 6.1% degradation was observed. No significant (p>0.05) degradation could be observed after heating in steam for 30 min at 100°C and after storage for four months at 4°C. From the results of an investigation of the degradation rate at elevated temperatures a negligible loss of content after a three years' storage period at 4°C could be predicted.


Public Health Phosphate Internal Medicine Elevated Temperature Degradation Rate 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • M. S. L. Kwee
    • 1
  • L. M. L. Stolk
    • 2
  1. 1.Faculty of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamTV AmsterdamThe Netherlands
  2. 2.Clinical Pharmacy DepartmentUniversity Hospital of AmsterdamAZ AmsterdamThe Netherlands

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