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Pharmaceutisch Weekblad

, Volume 11, Issue 2, pp 50–55 | Cite as

Retrospective analysis of drug treatment in epileptic patients

  • H. T. Rwiza
  • A. Keyser
  • Y. A. Hekster
  • M. Pool
  • H. Verwey
Original Articles

Abstract

An epidemiological analysis was performed of the adult, out-patient epilepsy clinic population of a university hospital during the period from 1 January 1981 through 30 June 1985. The number of patients that could be traced amounted to 590. An at random sample of 207 were retrospectively analysed. Gender distribution was male:female = 1.46. The mean age was 37.4 years. The diagnoses were classified according to the classification of the International League Against Epilepsy (ILAE). A preponderance of partial seizures was present, reflecting the selection in a university out-patient clinic of more difficult to treat forms of epilepsy. Antiepileptic drugs used in the treatment varied; monotherapy was obtained in 46% of the cases and carbamazepine was the most frequently prescribed drug (49%). Changes in seizure severity and factors associated with epilepsy are described. A discrepancy was found between the suspected drug levels, based upon the physician's judgement, and the plasma level measured in those patients in whom drug levels were monitored; factors interfering with clinical judgement are discussed.

Keywords

Anticonvulsants Drug monitoring, therapeutic Drug utilization Epidemiology Epilepsy 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1989

Authors and Affiliations

  • H. T. Rwiza
    • 1
  • A. Keyser
    • 1
  • Y. A. Hekster
    • 2
  • M. Pool
    • 1
  • H. Verwey
    • 1
  1. 1.Institute of NeurologySint Radboud HospitalHB Nijmegenthe Netherlands
  2. 2.Department of Clinical PharmacySint Radboud HospitalNijmegen

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