Advertisement

Pharmaceutisch Weekblad

, Volume 11, Issue 2, pp 44–49 | Cite as

The effect of food on the movement of pellets in the gastro-intestinal tract

  • Asterios Kyroudis
  • Sophia L. Markantonis
  • Arnold H. Beckett
Original Articles

Abstract

The effect of food on the movement of pellets in the gastro-intestinal tract was investigated in seven volunteers, either by means of X-rays taken after oral administration of barium sulfate pellets or by means of saliva concentration profiles of lithium obtained after oral administration of lithium sulfate controlled-release pellets. The X-ray studies showed that food had an effect on the time required for the pellets to leave the stomach and on their degree of dispersion in the small intestine, but not on other parameters. The studies with the lithium sulfate controlled-release pellets showed that food had a significant effect only in one in three subjects.

Keywords

Barium sulfate Biopharmaceutics Dissolution Food Lithium sulfate Pellets controlled release Radiography 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Galeone M, Nizzola L, Cacioli D, Moise G.In vivo demonstration of delivery mechanisms from sustainedrelease pellets. Curr Ther Res 1981;29:217–34.Google Scholar
  2. 2.
    Block BP, Thomas MB. A method for testing intestinal irritancy of sustained release KCl preparations in animals. J Pharm Pharmacol 1978;30:70P.Google Scholar
  3. 3.
    Beckett AH, Samaan AC, Ellis AC. Sustained release KCl products:in vitro-in vivo correlations. J Pharm Pharmacol 1978;30:69P.Google Scholar
  4. 4.
    Beckett AH. Controlled-release dosage forms. Pharm J 1983;Oct 8:402.Google Scholar
  5. 5.
    Bechgaard H, Christensen FN. Physiological factors and controlled release dosage forms. Pharm J 1982;229:373–6.Google Scholar
  6. 6.
    Beckett AH. Controlled release dosage forms. Pharm J 1983;Nov 5:538.Google Scholar
  7. 7.
    Feinblatt TM, Ferguson EA. Timed-disintegration capsules. Anin vivo roentgenographic study. N Engl J Med 1956;254:940–7.Google Scholar
  8. 8.
    Davis SS, Hardy JG, Taylor MJ, Whalley DR, Wilson G. The effect of food on the gastrointestinal transit of pellets and an osmotic device (Osmet). Int J Pharm 1984;21:331–40.Google Scholar
  9. 9.
    O'Reilly S, Wilson CG, Hardy JG. The influence of food on the gastric emptying of multiparticulate dosage forms. Int J Pharm 1987;34:213–6.Google Scholar
  10. 10.
    Davis SS, Khosla R, Wilson CG, Washington N. Gastrointestinal transit of a controlled-release pellet formulation of tiaprofenic acid and the effect of food. Int J Pharm 1987;35:253–8.Google Scholar
  11. 11.
    Kyroudis A.In vivo/in vitro correlation in rate-controlled drug delivery [Dissertation]. London: University of London, 1984:301–8.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1989

Authors and Affiliations

  • Asterios Kyroudis
    • 1
  • Sophia L. Markantonis
    • 2
  • Arnold H. Beckett
    • 3
  1. 1.The Appolo TowerAthensGreece
  2. 2.Department of PharmacyUniversity of AthensAthensGreece
  3. 3.Department of Pharmacy, Kings College LondonUniversity of LondonLondonGreat Britain

Personalised recommendations