Pharmaceutisch Weekblad

, Volume 14, Issue 3, pp 88–92 | Cite as

Centralized preparation of hazardous drugs

A choice between isolator and laminar airflow
  • P. Larrouturou
  • J. Huchet
  • M. -C. Taugourdeau
Practice/Case Reports


In 1987, the manager of the Saint-Joseph Hospital (Paris, France) requested a reorganization of cytotoxic drug preparation. Protection for staff who handle hazardous drugs was the main concern. The conclusions drawn from a first analysis emphasize the advantages of a centralized reconstitution unit against a decentralized system. Subsequently, a workload study and an economic study (investment, maintenance, supplies, staff costs, comparative balance sheet and a 5-year simulation) were carried out, but to choose between a laminar airflow in aseptic room and an isolator in a conventional room. The selected isolator is the first of the conception: the central half-suit uses as a server, and four sleeves located on one side allow two technicians to work in a sterile and closed area without sterile garments.


Antineoplastic agents Cost and cost analysis Drug compounding Equipment and supplies Isolator Laminar airflow hood 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Strücker I, Caillard JF, Collin R, Goux M, Poyen D, Hemon D. Risque d'avortement spontané et préparation des chimiothérapies anticancéreuses chez les infirmières. Paris: INSERM, 1988.Google Scholar
  2. 2.
    Kaijser GP, Underberg WJM, Beijnen JH. The risks of handling cytotoxic drugs. II. Recommendations for working with cytotoxic drugs. Pharm Weekbl [Sci] 1990;12(6):228–35.Google Scholar
  3. 3.
    Hoet P, Thorogood D. L'acide peracétique. In: Dauphin A, Darbord JC, eds. Hygiène hospitalière pratique. 2nd ed. Paris: Éditions Médicales Internationales, 1990:208–26.Google Scholar
  4. 4.
    Kline LB, Hull RN. The virucidal properties of peracetic acid. Am J Clin Pathol 1960:30–3.Google Scholar
  5. 5.
    Brazdova K, Nezval J, Velecky R. Bactericidal effect of spontaneously evaporated peracetic acid onPs. aeruginosa, St. pyogenes aureus, andB. subtilis. Scripta Medica 1965;38:107–13.PubMedGoogle Scholar
  6. 6.
    Baldry MGC. The bactericidal, fungicidal and sporicidal properties of hydrogen peroxyde and peracetic acid. J Appl Bacteriol 1983;54:417–23.PubMedGoogle Scholar
  7. 7.
    Portner DM, Huffman RK. Sporicidal effect of peracetic acid vapor. Appl Microbiol 1988;16:1782–5.Google Scholar
  8. 8.
    Huchet J, Taugourdeau M-C, Saint-Martin B, Larrouturou P. Daily functioning of a centralized reconstitution unit (C.R.U.) of antineoplastic drugs with an isolator system. In: Muller NF, Hekster YA, ed. Progress in clinical pharmacy, rational use of drugs. Noordwijk/Amsterdam: Medical Press, 1990:318–9.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • P. Larrouturou
    • 1
  • J. Huchet
    • 1
  • M. -C. Taugourdeau
    • 1
  1. 1.Department of PharmacySaint-Joseph HospitalParis CedexFrance

Personalised recommendations