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Pharmaceutisch Weekblad

, Volume 4, Issue 4, pp 93–103 | Cite as

Natural products in therapy

Prospects, goals and means in modern research
  • A. Baerheim Svendsen
  • J. J. C. Scheffer
Review Articles

Abstract

A review is presented which shows the vegetable kingdom as an almost inexhaustible reservoir of potential drugs. Some historical aspects about the use of plants and their constituents in medicine are dealt with. A number of problems connected with the search for new prototype drugs of biological origin is reported as well as modern methods used in this promising research. Some examples are given concerning recent results of investigations of plants used in traditional and modern medicine in China. Special attention is paid to the present role of natural products in therapy: as biologically active compounds as such, as starting materials for (semi)synthetic drugs and, last but not least, as source of inspiration or as models for the synthesis of new drugs with better therapeutic, chemical or physical properties than the original compounds.

Keywords

Public Health Internal Medicine Natural Product Active Compound Recent Result 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bernauer, K., F. Berlage, W. von Philipsborn, H. Schmid andP. Karrer (1958)Helv. Chim. Acta 41, 2293.Google Scholar
  2. Bhatnagar, S.S., andP.V. Divekar (1953)Indian J. Pharm. 15, 307; viaChem. Abstr. (1954)48, 8488b.Google Scholar
  3. Bognár, R., S. Makleit andT. Mile (1968)Magy. Kem. Folyoirat. 74, 526.Google Scholar
  4. Bovet, D., andF. Bovet-Nitti (1948)Experientia 4, 325.Google Scholar
  5. Cox.J.S.G., J.E. Beach, A.M.J.N. Blair, A.J. Clarke, J. King, T.B. Lee, D.E.E. Loveday, G.F. Moss, T.S.C. Orr, J.T. Ritchie andP. Sheard (1970) In:Advances in Drug Research (Harper, N.J., andA.B. Simmonds, Eds.). Academic Press, London-New York, 115.Google Scholar
  6. Drobot'ko, V.G., B.E.Aizenman and S.I.Zelepukha (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 135; viaChem. Abstr. (1959)53, 8229e.Google Scholar
  7. Euler, H. Von, andH. Erdtman (1935)Justus Liebigs Ann. Chem. 520, 1.Google Scholar
  8. Euler, H. Von, H. Erdtman andH. Hellström (1936)Ber. Dtsch. Chem. Ges. 69B, 743.Google Scholar
  9. Farnsworth, N.R. (1966)J. Pharm. Sci. 55, 225.Google Scholar
  10. Fitzmaurice, C., and T.B.Lee (1969)Brit. Pat. 1144905.Google Scholar
  11. Gábor, M. (1975)Abriss der Pharmakologie der Flavonoiden. Akadémiai Kiadó, Budapest.Google Scholar
  12. George, M., andK.M. Pandalai (1949)Indian J. Med. Res. 37, 169; viaChem. Abstr. (1950)44, 7493g.Google Scholar
  13. Gorlenko, M.V. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov,Leningr. Gos. Univ. Kiev, 57; viaChem. Abstr. (1959)53, 8228b.Google Scholar
  14. Gottshall, R.Y., E.H. Lucas, A. Lickfeldt andJ.M. Roberts (1949)J. Clin. Invest. 28, 920.Google Scholar
  15. Gottshall, R.Y., J.C. Jennings, L.E. Weller, C.T. Redemann, E.H. Lucas andH.M. Sell (1950)Am. Rev. Tuberc. 62, 475.Google Scholar
  16. Gran, L. (1973)The uteroactive principles of ‘KalataKalata’ (Oldenlandia affinis DC)., Ph.D. thesis, Bergen, Norway.Google Scholar
  17. Grewe, R. (1946)Naturwissenschaften 33, 333.Google Scholar
  18. Herrmann, E.C. Jr. (1961)Progr. Med. Virol. 3, 158.Google Scholar
  19. Hewitt, R.I., W.S. Wallace, E.R. Gill andJ.H. Williams (1952)Am. J. Trop. Hyg. 1, 768.Google Scholar
  20. Ieven, M., J. Totté, D. Vandenberghe andA.J. Vlietinck (1978)Planta Med. 33, 284.Google Scholar
  21. Irwin, S. (1962)Science 136, 123.Google Scholar
  22. Jang, C.S., F.Y. Fu, K.C. Huang andC.Y. Wang (1948)Nature 161, 400.Google Scholar
  23. Joshi, C.G., andN.G. Magar (1953)Indian J. Pharm. 15, 312; viaChem. Abstr. (1954)48, 8488g.Google Scholar
  24. Kartashova, N.N. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 62; viaChem. Abstr. (1959)53, 8228c.Google Scholar
  25. King, H. (1935)J. Chem. Soc. 1281.Google Scholar
  26. Knoll, J., S. Fürst andK. Kelemen (1973)J. Pharm. Pharmacol. 25, 929.Google Scholar
  27. Knoll, J., S. Fürst andS. Makleit (1975)J. Pharm. Pharmacol. 27, 99.Google Scholar
  28. Kobo, B. (1981)Pharmazie 36, 799.Google Scholar
  29. Komarova, M.A. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 84; viaChem. Abstr. (1959)53, 8228f.Google Scholar
  30. Löfgren, N. (1946)Arkiv Kemi Mineral. Geol. A 22, No. 18, 30 pp.Google Scholar
  31. Löfgren, N., andB. Lundqvist (1946)Svensk Kem. Tidskr. 58, 206.Google Scholar
  32. Lucas, E.H., A. Lickfeldt, R.Y. Gottshall andJ.C. Jennings (1951)Bull. Torrey Botan. Club 78, 310; viaChem. Abstr. (1951)45, 10296g.Google Scholar
  33. Malone, M.H. (1981) In:Proc. 7th Symposium Farmacognosie 1980 (Violon, Chr., V. Maes andA. Vercruysse, Eds.). Uitg. Vrije Universiteit Brussel, Brussels, 3.Google Scholar
  34. Narasimha Rao, P.L., andP.A. Kurup (1953)Indian J. Pharm. 15, 315; viaChem. Abstr. (1954)48, 8489a.Google Scholar
  35. Narasimha Rao, P.L., S.C.L. Verma, T.R. Gupta, D.V. Krishnamurti andT.B. Subba Rao (1953)Indian J. Pharm. 15, 316; viaChem. Abstr. (1954)48, 8489c.Google Scholar
  36. Noble, R.L. (1964)Proc. Intern. Pharmacol. Meeting, 2nd, Prague 1963, 63.Google Scholar
  37. Okazaki, K., andS. Oshima (1952)J. Pharm. Soc. Japan 72, 558; viaChem. Abstr. (1952)46, 8811b.Google Scholar
  38. Okazaki, K., H. Kato andT. Wakatabe (1951)J. Pharm. Soc. Japan 71, 1–9 and 89–112; viaChem. Abstr. (1951)45, 5365i and 6689a.Google Scholar
  39. Osborn, E.M. (1943)Brit. J. Exptl. Pathol. 24, 227.Google Scholar
  40. Sandberg, F. (1973)Nobel 25, Chemistry in botanical classification, 303.Google Scholar
  41. Sarett, L.H. (1946)J. Biol. Chem. 162, 601.Google Scholar
  42. Schönberg, A., andA. Sina (1950)J. Am. Chem. Soc. 72, 3396.Google Scholar
  43. Strauch, R., andK. Hiller (1974)Pharmazie 29, 656.Google Scholar
  44. Tang, W., andTh. Beyrich (1961)Pharmazie 16, 482.Google Scholar
  45. Tokin, B.P. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov, Leningr. Gos. Univ. Kiev, 5; viaChem. Abstr. (1959)53, 8227g.Google Scholar
  46. Vandenberghe, D.A., M. Ieven, F. Mertens andA.J. Vlietinck (1978)Lloydia 41, 463.Google Scholar
  47. Venkatesh, D.S., B. Bheemeswar andM. Sreenivasaya (1953)Indian J. Pharm. 15, 305; viaChem. Abstr. (1954)48, 8488a.Google Scholar
  48. Woo, Lin-K. (1959)Seoul Univ. J. 8, 322.Google Scholar
  49. Yakimov, P.A. (1957)Fitontsidy, Ikh Rol v Prirode. Izbrannye Dokl. 2-ogo Soveshch. po Probl. Fitontsidov,Leningr. Gos. Univ. Kiev, 132; viaChem. Abstr. (1954)53, 8229é.Google Scholar
  50. Yang, H.C., H.H. Chang andT.C. Weng (1953)J. Formosan Med. Assoc. 52, 109; viaChem. Abstr. (1953)47, 8175b.Google Scholar
  51. Xiao Peigen (1981) In:Natural Products as Medicinal Agents (Beal, J.L., andE. Reinhard, Eds.). Hippocrates Verlag, Stuttgart, 351.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • A. Baerheim Svendsen
    • 1
  • J. J. C. Scheffer
    • 1
  1. 1.Department of PharmacognosyState University of Leiden, Gorlaeus LaboratoriesRa LeidenThe Netherlands

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