Protective effect of acellular pertussis vaccines

  • M. Blennow
  • S. Hedenskog
  • M. Granström


Two acellular pertussis vaccines, a mono-component toxoid of pertussis toxin and a two-component vaccine containing both the toxoid and filamentous haemagglutinin, were used for primary immunization of infants 5 1/2 to 10 months of age in two clinical trials in Sweden. Over a follow-up period of 12 to 17 months, 37 children were exposed to pertussis in the household or a daycare centre. Only one child developed mild, culture-confirmed pertussis as opposed to the expected number of 30 to 33 cases based on an assumed attack rate of 80–90% in non-immunized children. These preliminary findings indicate that, given as primary immunization to infants, the vaccines provide protection against pertussis.


Clinical Trial Internal Medicine Protective Effect Pertussis Preliminary Finding 
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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1988

Authors and Affiliations

  • M. Blennow
    • 1
    • 2
  • S. Hedenskog
    • 3
  • M. Granström
    • 2
  1. 1.Department of PediatricsSachs' Childrens' HospitalStockholmSweden
  2. 2.Department of Vaccine ProductionNational Bacteriological LaboratoryStockholmSweden
  3. 3.Department of PediatricsUniversity of LinköpingLinköpingSweden

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