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Protective effect of acellular pertussis vaccines

  • M. Blennow
  • S. Hedenskog
  • M. Granström
Article

Abstract

Two acellular pertussis vaccines, a mono-component toxoid of pertussis toxin and a two-component vaccine containing both the toxoid and filamentous haemagglutinin, were used for primary immunization of infants 5 1/2 to 10 months of age in two clinical trials in Sweden. Over a follow-up period of 12 to 17 months, 37 children were exposed to pertussis in the household or a daycare centre. Only one child developed mild, culture-confirmed pertussis as opposed to the expected number of 30 to 33 cases based on an assumed attack rate of 80–90% in non-immunized children. These preliminary findings indicate that, given as primary immunization to infants, the vaccines provide protection against pertussis.

Keywords

Clinical Trial Internal Medicine Protective Effect Pertussis Preliminary Finding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Pittman, M. Pertussis toxin: the cause of the harmful effects and prolonged immunity of whooping cough. A hypothesis. Reviews of Infectious Diseases 1979, 1: 401–412.Google Scholar
  2. 2.
    Robinson, A., Irons, L. I., Ashworth, L. A. Pertussis vaccine: present status and future prospects. Vaccine 1985, 3: 11–22.CrossRefPubMedGoogle Scholar
  3. 3.
    Manclark, C. R., Burns, D. L. Prospects for a new acellular pertussis vaccine. Annales de Microbiologie 1985, 136: 323–329.Google Scholar
  4. 4.
    Sato, Y., Kimura, M., Fukumi, H. Development of a pertussis component vaccine in Japan. Lancet 1984, i: 122–126.CrossRefGoogle Scholar
  5. 5.
    Aoyama, T., Murase, Y., Kato, T., Iwata, T. Efficacy of an acellular pertussis vaccine in Japan. Journal of Pediatrics 1985, 107: 180–183.PubMedGoogle Scholar
  6. 6.
    Blennow, M., Granström, M., Olin, P., Tiru, M., Jäätmaa, E., Askelöf, P., Sato, Y. Preliminary data from a clinical trial (phase 2) of an acellular pertussis vaccine, JNIH-6. Developments in Biological Standardization 1986, 65: 185–190.PubMedGoogle Scholar
  7. 7.
    Hedenskog, S., Granström, M., Olin, P., Tiru, M., Sato, Y. A clinical trial of a monocomponent pertussis toxoid vaccine. American Journal of Diseases of Children 1987, 141: 844–847.PubMedGoogle Scholar
  8. 8.
    Granström, M., Granström, G., Gillenius, P., Askelöf, P. Neutralizing antibodies to pertussis toxin in whooping cough. Journal of Infectious Diseases 1985, 151: 646–649.PubMedGoogle Scholar
  9. 9.
    Granström, M., Granström, G., Lindfors, A., Askelöf, P. Serologic diagnosis of whooping cough by an enzyme-linked immunosorbent assay using fimbrial hemagglutinin as antigen. Journal of Infectious Diseases 1982, 146: 741–745.PubMedGoogle Scholar
  10. 10.
    Daniel, W. W. Biostatistics: a foundation for analysis in the health sciences. John Wiley and Sons, New York, 1983, p. 66–73.Google Scholar
  11. 11.
    Lapin, J. H. Whooping cough. Charles C. Thomas, Springfield, 1943, p. 8–9.Google Scholar
  12. 12.
    Medical Research Council The prevention of whooping-cough by vaccination. British Medical Journal 1951, i: 1463–1471.Google Scholar
  13. 13.
    Broome, C. V., Preblud, S. R., Bruner, B., McGowan, J. E., Hayes, P. S., Harris, P. P., Elsea, W., Fraser, D. W. Epidemiology of pertussis, Atlanta, 1977. Journal of Pediatrics 1981, 98: 362–367.PubMedGoogle Scholar
  14. 14.
    Noble, G., Bernier, R., Esber, E. C., Hardegree, M. C., Hinman, A. R., Klein, D., Saah, A. J. Acellular and whole-cell pertussis vaccines in Japan. Report of a visit by US scientists. Journal of the American Medical Association 1987, 257: 1351–1356.CrossRefPubMedGoogle Scholar
  15. 15.
    Strangert, K. Respiratory illness in preschool children with different forms of day care. Pediatrics 1976, 57: 191–196.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1988

Authors and Affiliations

  • M. Blennow
    • 1
    • 2
  • S. Hedenskog
    • 3
  • M. Granström
    • 2
  1. 1.Department of PediatricsSachs' Childrens' HospitalStockholmSweden
  2. 2.Department of Vaccine ProductionNational Bacteriological LaboratoryStockholmSweden
  3. 3.Department of PediatricsUniversity of LinköpingLinköpingSweden

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