Advertisement

Pharmaceutisch Weekblad

, Volume 5, Issue 4, pp 182–183 | Cite as

Org 4333, a potent, irreversibly binding estrogen agonist

  • A. J. van den Broek
  • J. Leemhuis
  • M. S. de Winter
  • F. J. Zeelen
Short Communications

Abstract

Two synthetic routes to 11β-chloromethylestra-1,3,5(10)-trien-3,17β-diol (Org 4333) are described. In biological tests this compound was found to be a potent irreversibly binding estrogen agonist.

Keywords

Public Health Internal Medicine Estrogen Synthetic Route Biological Test 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Allen, E., andE.A. Doisy (1923)JAMA 81, 819.Google Scholar
  2. Bose, A.K., and B.Lal (1973)Tetrahedron Leu. 3937.Google Scholar
  3. Broek, A.J. V.D., A.I.A. Broess, M.J. V.D. Heuvel, H.P. de Jongh, J. Leemhuis, K.H. Schönemann, J. Smits, J. de Visser, N.P. van Vliet andF.J. Zeelen (1977)Steroids 30, 481.CrossRefPubMedGoogle Scholar
  4. Katzenellenbogen, J.A. (1982) Personal communication.Google Scholar
  5. Lauson, H.D., C.G. Heller, J.B. Golden andE.L. SevrinGhaus (1939)Endocrinology 24, 35.Google Scholar
  6. Leclercq, G., N. DEVleeschouwer and J.C.Heuson (1982) vi International Congress on Hormonal Steroids, Jerusalem.Google Scholar
  7. Leclercq, G., N. de Vleeschouwer, N. Legros andJ.C. Heuson (1980) In:Cytotoxic Estrogens in Hormone Receptive Tumors (Raus, J., H. Martens andG. Leclercq, Eds). Academic Press, London.Google Scholar
  8. Muhlbock, O. (1940)Acta Brev. Neerl. Physiol. 10, 42.Google Scholar
  9. Payne, D.W., andJ.A. Katzenellenbogen (1979)Endocrinology 105, 742.Google Scholar
  10. Ratajczak, T., P.N. Sheppard, R.J. Capon andR. Hähnel (1981)Steroids 38, 537.CrossRefPubMedGoogle Scholar
  11. Robertson, D.W., L.L. Wei, J.R. Hayes, K.E. Carlson, J.A. Katzenellenbogen andB.S. Katzenellenbogen (1981)Endocrinology 109, 1298.PubMedGoogle Scholar
  12. Schönemann, K.H., N.P. van Vliet andF.J. Zeelen (1980)Eur. J. Med. Chem. 15. 333.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • A. J. van den Broek
    • 1
  • J. Leemhuis
    • 1
  • M. S. de Winter
    • 1
  • F. J. Zeelen
    • 1
  1. 1.Scientific Development GroupOrganonBH OssThe Netherlands

Personalised recommendations