Screening for impurities in butoprozine
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The purity analysis of butoprozine is described. Both gas chromatography-mass spectrometry (Gc-ms) and high pressure liquid chromatography (Hplc) withUv-vis detection (conventional and multichannel) were used. In the butoprozine example disadvantages for both techniques became apparent: incorrect conclusions with regard to the purity of the drug would have been drawn if only one of these Chromatographic techniques had been used.Gc-ms allowed the identification of an impurity not found byHPLC.
KeywordsPublic Health Internal Medicine Liquid Chromatography High Pressure High Pressure Liquid Chromatography
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