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Pharmaceutisch Weekblad

, Volume 5, Issue 4, pp 149–152 | Cite as

Screening for impurities in butoprozine

  • B. F. H. Drenth
  • T. Jagersma
  • A. J. G. Wormeester
  • R. A. de Zeeuw
Original Articles
  • 17 Downloads

Abstract

The purity analysis of butoprozine is described. Both gas chromatography-mass spectrometry (Gc-ms) and high pressure liquid chromatography (Hplc) withUv-vis detection (conventional and multichannel) were used. In the butoprozine example disadvantages for both techniques became apparent: incorrect conclusions with regard to the purity of the drug would have been drawn if only one of these Chromatographic techniques had been used.Gc-ms allowed the identification of an impurity not found byHPLC.

Keywords

Public Health Internal Medicine Liquid Chromatography High Pressure High Pressure Liquid Chromatography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • B. F. H. Drenth
    • 1
  • T. Jagersma
    • 1
  • A. J. G. Wormeester
    • 1
  • R. A. de Zeeuw
    • 1
  1. 1.Laboratory for Pharmaceutical and Analytical Chemistry, Department of ToxicologyState UniversityAW GroningenThe Netherlands

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