Pharmaceutisch Weekblad

, Volume 5, Issue 3, pp 109–113 | Cite as

Analysis of creams

V. Application of thin layer chromatography. Part I
  • F. J. Van De Vaart
  • A. Hulshoff
  • A. W. M. Indemans
Original Articles


A standard procedure, consisting of twotlc systems, for the qualitative control of creams is presented. All common cream excipients, except those of very high polarity, are separated in a simple gradient elution system, using diethyl ether as the eluent in a chromatographic chamber saturated withn-pentane. The very polar cream base components are separated usingn-butanol-glacial acetic acid-water (20+2+5) as the eluent. The chromatographic behaviour of common cream excipients as well as threefna cream bases and four commercial cream bases is discussed.


Acetic Ether Internal Medicine Standard Procedure Diethyl 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1983

Authors and Affiliations

  • F. J. Van De Vaart
    • 1
  • A. Hulshoff
    • 2
  • A. W. M. Indemans
    • 1
    • 2
  1. 1.Laboratory of the Dutch PharmacistsJL The HagueThe Netherlands
  2. 2.Pharmaceutical Laboratory, Department of Analytical PharmacyUniversity of UtrechtGH UtrechtThe Netherlands

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