Pharmaceutisch Weekblad

, Volume 9, Issue 2, pp 98–103 | Cite as

Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients

  • Roelof Van Dalen
  • Tom B. Vree
  • Ita M. Baars
Pharmacokinetics and Organ Dysfunction


A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased elimination but, due to increased apparent volumes of distribution, prolonged half-life times were observed. Consequently, in patients with complicated disease states a dosage regimen should be based on pharmacokinetic studies performed in a similar patient group.

Key words

Cefoxitin Ceftazidime Ceftriaxone Cefuroxime Chromatography, high pressure liquid Kidney diseases Pharmacokinetics Protein binding 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • Roelof Van Dalen
    • 1
  • Tom B. Vree
    • 2
  • Ita M. Baars
    • 2
  1. 1.Department of Intensive CareSt. Radboud HospitalHB NijmegenThe Netherlands
  2. 2.Department of Clinical PharmacySt. Radboud HospitalHB NijmegenThe Netherlands

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