, Volume 35, Issue 5, pp 696–699 | Cite as

Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate

  • T. Saito
  • T. Nohno
  • H. Yoshida
  • H. Yokoya


Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) antagonized the effect of exogenous androgens on the ventral prostate (VP) in castrated rats as well as the effect of endogenous androgens in intact rats. FA, however, had no effect on the seminal vesicles (SV) and levator ani muscle (LAM), nor oestrogenic effect in female rats and mice. FA did not antagonize the receptor binding of testosterone nor inhibit the conversion of testosterone into 5α-dihydrotestosterone (DHT).


Testosterone Androgen Receptor Binding Ferulic Acid Seminal Vesicle 
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  1. 4.
    L. G.Hirschberger, E. G. Shipley and R. K. Meyer, Proc. Soc. exp. Biol. N. Y.83, 175 (1953).Google Scholar
  2. 5.
    B. T. Rubin, A. S. Dorfman, L. Black and R. I. Dorfman, Endocrinology49, 429 (1951).Google Scholar
  3. 6.
    M. X. Zarrow, J. M. Yochim and J. L. McCarthy, in: Experimental Endocrinology, p. 40. Academic Press, New York 1964.Google Scholar
  4. 7.
    N. Bruchovsky, P. S. Rennie and A. Vanson, Biochim. biophys. Acta394, 248 (1975).Google Scholar
  5. 8.
    K. Burton, in: Methods in Enzymology, XII, part B, p. 163. Academic Press, New York 1968.Google Scholar
  6. 9.
    O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, J. biol. Chem.193, 265 (1951).Google Scholar
  7. 10.
    D. K. H. Lee, J. C. Young, Y. Tamura, D. C. Patterson, C. E. Bird and A. F. Clark, Can. J. Biochem.51, 735 (1973).Google Scholar
  8. 11.
    P. B. Coulson and E. J. Pavlik, J. Steroid Biochem.8, 205 (1977).Google Scholar
  9. 12.
    H. J. Helminen and J. L. E. Ericsson, J. Ultrastr. Res.36, 708 (1971).Google Scholar
  10. 13.
    D. Brandes, in: Male Accessory Sex Organs, p. 184. Academic Press, New York 1974.Google Scholar
  11. 14.
    H. Chiodi, C. r. Soc. Biol. (Paris),129, 866 (1938).Google Scholar
  12. 15.
    H. Chiodi, C. r. Soc. Biol. (Paris)130, 457 (1939).Google Scholar
  13. 16.
    K. Korenchevsky, K. Hall and M. A. Ross, Biochem. J.31, 467 (1937).Google Scholar
  14. 17.
    H. C. Browning, I. K. Hawkins and L. M. Holmberg, Texas Rep. Biol. Med.19, 753 (1961).Google Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • T. Saito
    • 1
    • 2
  • T. Nohno
    • 1
    • 2
  • H. Yoshida
    • 1
    • 2
  • H. Yokoya
    • 1
    • 2
  1. 1.Department of PharmacologyKawasaki Medical SchoolKurashiki(Japan)
  2. 2.Department of PharmacologyIwate Medical University School of DentistryMorioka(Japan)

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