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Experientia

, Volume 35, Issue 5, pp 571–572 | Cite as

Leonurine, an improved synthesis

  • K. F. Cheng
  • C. S. Yip
  • H. W. Yeung
  • Y. C. Kong
Specialia

Summary

Leonurine (1) is the uterotonic principle ofLeonurus artemisia. We have developed a simple, high-yield synthetic procedure of1 that is adaptable to large scale preparation. The synthesis involves the condensation of syringic acid and 4-guanidino-1-butanol hydrochloride in the presence of DDC using 1∶1 HMPT-ether as solvent. The synthetic leonurine showed uterotonic activity in vivo and in vitro.

Keywords

Hydrochloride Synthetic Procedure Syringic Acid Large Scale Preparation Scale Preparation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • K. F. Cheng
    • 1
    • 2
  • C. S. Yip
    • 1
    • 2
  • H. W. Yeung
    • 1
    • 2
  • Y. C. Kong
    • 1
    • 2
  1. 1.Chemistry DepartmentUniversity of Hong Kong(Hong Kong)
  2. 2.Biochemistry DepartmentChinese University of Hong Kong(Hong Kong)

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