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Pharmaceutisch Weekblad

, Volume 6, Issue 1, pp 18–20 | Cite as

Rectal absorption of metronidazol from polyethylene glycol suppositories

  • H. Vromans
  • F. Moolenaar
  • J. Visser
  • D. K. F. Meijer
Short Communications

Abstract

The rectal absorption of metronidazol from an aqueous suspension, a fatty suppository and three different polyethylene glycol suppositories was studied in healthy volunteers and compared with absorption from an oral solution. Rectal absorption was found to be rather slow for all suppositories. Of all rectal dosage forms, the polyethylene glycol suppositories gave the highest peak plasma levels and the highest relative bioavailability. Compared with oral administration, a relative bioavailability of 80% could be obtained.

Keywords

Glycol Healthy Volunteer Plasma Level Oral Administration High Peak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • H. Vromans
    • 1
  • F. Moolenaar
    • 1
  • J. Visser
    • 1
  • D. K. F. Meijer
    • 1
  1. 1.Department of Pharmacology and Pharmacotherapeutics, Subfaculty of PharmacyState University of GroningenAW GroningenThe Netherlands

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