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Pharmaceutisch Weekblad

, Volume 6, Issue 1, pp 11–15 | Cite as

Determination by flameless atomic absorption of aluminium in serum and hair for toxicological monitoring of patients on chronic intermittent haemodialysis

  • H. J. De Groot
  • E. J. M. De Haas
  • P. D'Haese
  • A. Heyndrickx
  • F. A. De Wolff
Original Articles

Abstract

Determination of aluminium in serum of patients on chronic intermittent haemodialysis is of paramount importance in the prevention or early diagnosis of aluminium intoxication. We present a new method based on flameless atomic absorption spectroscopy, in which the serum matrix is destroyed by oxygen. A comparison has been made between the described method and another procedure which is used in the Laboratory of Toxicology in Gent, with favourable results. In addition, a method is presented for the determination of aluminium in hair, in which special attention has been paid to the cleaning of the hair samples prior to destruction. As yet it cannot be concluded whether aluminium concentrations in hair give a better representation of the body burden than serum levels do.

Keywords

Oxygen Public Health Aluminium Internal Medicine Serum Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • H. J. De Groot
    • 1
  • E. J. M. De Haas
    • 1
  • P. D'Haese
    • 2
  • A. Heyndrickx
    • 2
  • F. A. De Wolff
    • 1
  1. 1.Laboratory of ToxicologyUniversity HospitalAA LeidenThe Netherlands
  2. 2.Laboratory of ToxicologyState UniversityGentBelgium

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