Distinction between the tautomeric forms of sulfanilamide derivatives by13C- NMR
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The application of13C-nmr for the distinction between amido and imido tautomers of sulfanilamide derivatives indmso solution is described. The differentiation is based on Δδ, the change in chemical shift of a sulfanilamide from the neutral form (indmso solution) to the anion (in aqueous alkaline solution). The Δδ values of three C atoms (C1, C1′, C4) are suitable for the differentiation between the tautomers. The conclusions confirm previous results.