Advertisement

Pharmaceutisch Weekblad

, Volume 8, Issue 3, pp 194–197 | Cite as

Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at −20° C and thawing by microwave radiation

  • L. Keusters
  • L. M. L. Stolk
  • R. Umans
  • P. van Asten
Original Articles

Abstract

Doxorubicin and epirubicin solutions in plastic minibags for intravesical use were stored at −20° C and thawed at room temperature or by microwave radiation. Concentrations were measured with HPLC and TLC. Doxorubicin and epirubicin solutions could be frozen and stored at −20° C during at least two and four weeks, respectively, and subsequently thawed without loss of content. When the thawed doxorubicin solutions were refrozen and thawed again five weeks later, only a slight decrease of content was measured.

Key words

Doxorubicin Epirubicin Freezing Quantitative analysis Stability Sterilization Thawing, microwave radiation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Trissel LA. Handbook on injectable drugs. 3rd ed. Bethesda: American Society of Hospital Pharmacists, 1983.Google Scholar
  2. 2.
    Beijnen JH, Wiese G, Underberg WJM. Aspects of the chemical stability of doxorubicin and seven other anthracyclines in acidic solution. Pharm Weekbl [Sci] 1985;7:109–16.Google Scholar
  3. 3.
    Ausman RK, Holmes CJ, Water CW, Kundsin RB. The application of a freeze-microwave thaw technique to central admixtures services. Drug Intell Clin Pharm 1980;14:284–7.Google Scholar
  4. 4.
    Hoffman DM, Grossano DD, Damin LA, Woodcock TM. Stability of refrigerated and frozen solutions of doxorubicin hydrochloride. Am J Hosp Pharm 1979;36:1536–8.Google Scholar
  5. 5.
    Karlsen J, Hjort Thonnessen H, Resberg Olsen I, Horne Sollien A, Skobba TJ. Stability of cytotoxic intravenous solutions subjected to freeze-thaw treatment. Nord Pharm Acta 1983;45:61–7.Google Scholar
  6. 6.
    Cummings J, Stuart JFB, Calman KC. Determination of adriamycin, adriamycinol and their 7-deoxyaglycones in human serum by high performance liquid chromatography. J Chromatogr 1984;311:125–33.Google Scholar
  7. 7.
    Benjamin RS, Riggs CE, Bachur NR. Plasma pharmacokinetics of adriamycin and its metabolites in humans with normal hepatic and renal function. Cancer Res 1977;37:1416–20.Google Scholar
  8. 8.
    Tomecko GW, Kleinberg ML, Latiolais CJ, Prior RB, Pesko LJ, Jones BC. Stability of cefazolin sodium admixtures in plastic bags after thawing by microwave radiation. Am J Hosp Pharm 1980;37:211–5.Google Scholar
  9. 9.
    Elliott GT, McKenzie MW, Curry SH, Pieper JA, Quinn SL. Stability of cimetidine hydrochloride in admixtures after microwave thawing. Am J Hosp Pharm 1983;40:1002–6.Google Scholar
  10. 10.
    Kana MJ. Microwave oven explosion. Hosp Pharm 1980;15:104.Google Scholar
  11. 11.
    Ausman RK, Kerkhof K, Holmes CJ, Cantwell R, Kundsin RB, Walter CW. Frozen storage and microwave thawing of parenteral nutrition solutions in plastic containers. Drug Intell Clin Pharm 1981;15:440–3.Google Scholar
  12. 12.
    Tomlinson R, Malspeis L. Concomitant adsorption and stability of some anthracycline antibiotics. J Pharm Sci 1982;71:1121–5.Google Scholar
  13. 13.
    Weast RC, Selby SM, eds. Handbook of chemistry and physics. 47th ed. Cleveland: Chemical Rubber Co., 1966:A-244.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1986

Authors and Affiliations

  • L. Keusters
    • 1
  • L. M. L. Stolk
    • 2
  • R. Umans
    • 3
  • P. van Asten
    • 1
    • 4
  1. 1.Department of Pharmacy, Division for Practical and Social PharmacyState University of UtrechtGH UtrechtThe Netherlands
  2. 2.Department of Pharmacy, Academic Medical CentreUniversity Hospital of AmsterdamAZ AmsterdamThe Netherlands
  3. 3.Department of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamTV AmsterdamThe Netherlands
  4. 4.Department of PharmacyUniversity Hospital of UtrechtGV UtrechtThe Netherlands

Personalised recommendations