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Pharmaceutisch Weekblad

, Volume 10, Issue 4, pp 170–172 | Cite as

The suitability of some preservatives in chloroquine phosphate syrup

  • H. Van Doorne
  • N. F. Wieringa
  • E. H. Bosch
  • R. De Meijer
Short Communications

Abstract

In Third World countries chloroquine phosphate syrup is frequently prepared with chloroform as a preservative. Because of the toxic side effects of chloroform the suitability of a number of possible alternatives were investigated. If the chloroquine phosphate syrup is prepared as such, the combination of sorbic acid (1.5 g/l) and citric acid (2 g/l) is preferred. If, however, the chloroquine phosphate syrup is prepared from a stock solution of simple syrup, the relatively low pH may be undesirable, because it may negatively affect the stability or solubility of other medicinal compounds. For a stock solution of simple syrup the combination of methyl paraben (1.8 g/l) and propyl paraben (0.2 g/l) is preferred. Good care must be taken that a layer of condense water cannot be formed.

Keywords

Chloroquine Citric acid Drug stability Parabens Preservatives, pharmaceutical Sorbic acid Syrup 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1988

Authors and Affiliations

  • H. Van Doorne
    • 1
  • N. F. Wieringa
    • 1
  • E. H. Bosch
    • 1
  • R. De Meijer
    • 1
  1. 1.Department of PharmacyState University of GroningenAW Groningenthe Netherlands

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