The bioavailability of three altretamine formulations
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The bioavailability of two altretamine preparations was studied in a randomized cross-over design. The two preparations were compared with a third in a parallel design. Dissolution differences between the preparations were observed, which could give rise to differences in bioavailability caused by the extensive first-pass effect of altretamine. Thein vivo data showed a trend to differences in bioavailability.
KeywordsAltretamine Biological availability Metabolism Pharmacokinetics
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- 4.D'Incalci M, Beggiolin G, Sessa C, Mangioni C. Influence of ascites on the pharmacokinetics of hexamethylmelamine andN-demethylated metabolites in ovarian cancer patients. Eur J Cancer Clin Oncol 1981;12:1331–5.Google Scholar
- 8.Worzalla JF, Johnson BM, Ramirez G, Bryan GT.N-Demethylation of the antineoplastic agent hexamethylmelamine by rats and man. Cancer Res 1973;33:2810–5.Google Scholar
- 13.Van de Vaart-van Zutphen HPC, Smulders CFA, Renema J, Hulshoff A. Hexamethylmelamine and hexamethylmelamine hydrochloride. Pharm Weekbl [Sci] 1982;4:25–31.Google Scholar
- 14.Barnes TC, Frances S. Toxicity of hexamethylmelamine (NSC-13875) in rats. Arch Int Pharmacodyn 1966;160:8–95.Google Scholar
- 20.Steinijans VW, Diletti E. Generalization of distribution free confidence intervals for bioavailability ratios. Eur J Clin Pharmacol 1985;28:85–8.Google Scholar
- 22.Grizzle JE. The two-period change-over design and its use in clinical trials. Correction. Biometrics 1974;30:727.Google Scholar