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Pharmaceutisch Weekblad

, Volume 7, Issue 6, pp 267–272 | Cite as

Generalized theory for two-phase ion-pair and complexometric titrations

II. Two-phase titrations with side reactions
  • A. Bult
  • H. A. Dingjan
  • S. M. Dreijer-van der Glas
  • W. P. Van Bennekom
Original Articles

Abstract

For the two-phase titration based on ion-pair and metal-complex formation full attention is given to side reactions in both phases. Their significance for the applicability of this type of titration is evaluated. Side reactions in the aqueous phase diminish and in the organic phase promote the ‘titratability’. Equations for the calculation of the side reaction coefficients, the titration curve and the selection of the optimal pH and minimal side reaction interference (in the aqueous phase) are presented. Finally a full description is given of the two-phase titration including all parameters determining the ‘titratability’. The merits of the developed theory are illustrated by literature examples.

Keywords

Public Health Internal Medicine Aqueous Phase Generalize Theory Organic Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1985

Authors and Affiliations

  • A. Bult
    • 1
  • H. A. Dingjan
    • 1
  • S. M. Dreijer-van der Glas
    • 1
  • W. P. Van Bennekom
    • 1
  1. 1.Department of Pharmaceutical Analysis, Subfaculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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