Pharmaceutisch Weekblad

, Volume 7, Issue 6, pp 237–244 | Cite as

Cisplatin: a review of clinical applications and renal toxicity

  • Dirk Th. Sleijfer
  • Sijtze Meijer
  • Nanno H. Mulder
Review Articles


In reviewing the literature about the clinical application ofcis-diamminedichloroplatinum(II) (cisplatin) it can be concluded that the availability of cisplatin has been an important advance in cancer chemotherapy; especially in patients with disseminated testicular carcinoma and ovarian cancer cisplatin-based combinations are the first choice treatment. Our own investigations of the nature of the main form of toxicity of cisplatin, the nephrotoxicity, are mentioned and methods of its prevention are summarized.


Public Health Carcinoma Internal Medicine Ovarian Cancer Clinical Application 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1985

Authors and Affiliations

  • Dirk Th. Sleijfer
    • 1
  • Sijtze Meijer
    • 2
  • Nanno H. Mulder
    • 1
  1. 1.Department of Medical OncologyUniversity Hospital GroningenEZ GroningenThe Netherlands
  2. 2.Department of NephrologyUniversity Hospital GroningenEZ GroningenThe Netherlands

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