Pharmaceutisch Weekblad

, Volume 4, Issue 6, pp 165–171 | Cite as

Leukotrienes, allergy and inflammation

  • F. P. Nijkamp
  • J. M. A. Sitsen
Review Articles


Immunological and non-immunological injury induce as a result of the action of the enzyme lipoxygenase the release of a series of arachidonic acid metabolites known as leukotrienes. The leukotrienes play an important role in allergic and inflammatory disease. Leukotrienes C4, D4 and E4 which recently have been recognized as constituents of the allergic mediator slow reacting substance of anaphylaxis (srs-a) induce powerful bronchoconstriction, plasma exudation and weal and flare responses. Leukotriene B4 is involved in the regulation of chemotaxis, chemokinesis and other aspects of both cellular and vascular inflammation.

The development of specific lipoxygenase inhibitors may lead to a new class of drugs for the treatment of bronchial asthma and chronic inflammatory diseases.


Public Health Asthma Internal Medicine Arachidonic Acid Inflammatory Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Anonymus (1982)New Scientist 94, no. 1299, 8.Google Scholar
  2. Armour, C.L., J.M. Hughes, J.P. Seale andD.M. Temple (1981)Eur. J. Pharmacol. 72, 93–96.Google Scholar
  3. Austen, K.F. (1982) Presentation at the V International Conference on Prostaglandins, Florence (Italy), May 18–21.Google Scholar
  4. Blackwell, G.J., R.J. Flower, F.P. Nijkamp andJ.R. Vane (1978)Br. J. Pharmacol. 62, 79–89.Google Scholar
  5. Blackwell, G.J., R. Carnuccìo, M. Di Rosa, R.J. Flower, L. Parente andP. Persico (1980)Nature 287, 147–149.Google Scholar
  6. Bokoch, G.M., andP.W. Reed (1981)J. Biol. Chem. 256, 5317–5320.Google Scholar
  7. Borgeat, P., andB. Samuelsson (1979)Proc. Nat. Acad. Sci. U.S.A. 76, 3213–3217.Google Scholar
  8. Borgeat, P., andP. Sirois (1981)J. Med. Chem. 24, 121–126.Google Scholar
  9. Bray, M.A., F.M. Cunningham andA.W. Ford-Hutchinson (1981)Br. J. Pharmacol. 72, 483–486.Google Scholar
  10. Burke, J.A., R. Levi, Z.G. Guo andE.J. Corey (1981)J. Pharmacol. Exp. Therap. 221, 235–241.Google Scholar
  11. Cromwell, O., H.R. Morris, M.E. Hodson, M.J. Walport, G.W. Taylor andJ. Batten (1981)Lancet II, 164–165.Google Scholar
  12. Dahlen, S.E., J. Björk, P. Hedqvist, K.E. Arfors, S. Hammerström, J.Å. Lindgren andB. Samuelsson (1981)Proc. Nat. Acad. Sci. U.S.A. 78, 3887–3891.Google Scholar
  13. Davidson, E.M., S.A. Rae andM.J.H. Smith (1982)J. Pharm. Pharmacol. 34, 410.Google Scholar
  14. Drazen, J.M., K.F. Austen, R.A. Lewis, D.A. Clark, G. Goto, A. Marfat andE.J. Corey (1980)Proc. Nat. Acad. Sci. U.S.A. 77, 4354–4358.Google Scholar
  15. Feldberg, W.S., andC.H. Kellaway (1938)J. Physiol. 94, 187–226.Google Scholar
  16. Ford-Hutchinson, A.W., M.A. Bray, M.V. Doig, M.E. Shipley andM.J.H. Smith (1980)Nature 286, 264–265.Google Scholar
  17. Goetzl, E.J. (1980)New Engl. J. Med. 303, 822–825.Google Scholar
  18. Goetzl, E.J., andF.F. Sun (1979)J. Exp. Med. 150, 406–411.Google Scholar
  19. Goetzl, E.J., andW.C. Pickett (1980)J. Immunol. 125, 1789–1791.Google Scholar
  20. Goetzl, E.J., J.M. Woods andR.R. Gorman (1977)J. Clin. Invest. 59, 179–183.Google Scholar
  21. Hansson, G., J.A. Lindgren, S.E. Dahlen, P. Hedqvist andB. Samuelsson (1981)FEBS Lett. 130, 107–112.Google Scholar
  22. Harkavy, J. (1930)J. Arch. Int. Med. 45, 641–646.Google Scholar
  23. Higgs, G.A., S. Moncada andJ.R. Vane (1979) In:Advances in inflammation Research, Vol. I (Weismann, G., B. Samuelsson andR. Paoletti, Eds.). Raven Press, New York, 413–418.Google Scholar
  24. Hoek, J.Y. Van Der, R.W. Bryant andJ.M. Bailey (1980)J. Biol. Chem. 255, 10064–10065.Google Scholar
  25. Holroyde, M.C., M. Cole, R.E.C. Altounyan, M. Dixon andE.V. Elliott (1981)Lancet II, 17–18.Google Scholar
  26. Jakschik, B.A., S. Falkenhein andC.W. Parker (1977)Proc. Nat. Acad. Sci. U.S.A. 74, 4577–4581.Google Scholar
  27. Klickstein, L.B., C. Shapleigh andE.J. Goetzl (1980)J. Clin. Invest. 66, 1166–1170.Google Scholar
  28. Letts, L.G., andP.J.L. Piper (1982)Br. J. Pharmacol. 76, 169–176.Google Scholar
  29. Lewis, R.A., andK.F. Austen (1981)Nature 293, 103–108.Google Scholar
  30. Lewis, R.A., N.A.Soter, E.J.Corey and K.F.Austen (1981)Clin. Res. 29, abstr. 492a.Google Scholar
  31. Lewis, R.A., J.M. Drazen, J.C. Figueiredo, E.J. Corey andK.F. Austen (1982)Int. J. Immunopharmacol. 4, 85–90.Google Scholar
  32. Michoud, M.C., P.D. Pare, R.P. Orange andJ.C. Hogg (1979)Am. Rev. Resp. Dis. 119, 419–424.Google Scholar
  33. Nijkamp, F.P., andA.G.M. Ramakers (1980)Eur. J. Pharmacol. 62, 121–122.Google Scholar
  34. Nijkamp, F.P., R.J. Flower, S. Moncada andJ.R. Vane (1976)Nature 263, 479–482.Google Scholar
  35. Patterson, R., andK.E.J. Harris (1981)Allergy Clin. Immunol. 67, 146–152.Google Scholar
  36. Peters, S.P., M.I. Siegel, A. Kagey-Sobotka andL.M. Lichtenstein (1981)Nature 292, 455–457.Google Scholar
  37. Piper, P.J., andM.M. Samhoun (1981)Prostaglandins 21, 793–803.Google Scholar
  38. Saeed, S.A., M. Drew andH.O.J. Collier (1980)Eur. J. Pharmacol. 67, 169–170.Google Scholar
  39. Sekiya, K., andH. Okuda (1982)Biochem. Biophys. Res. Commun. 105, 1090–1095.Google Scholar
  40. Smedegård, G., P. Hedqvist, S.E. Dahlen, B. Revenäs, S. Hammerström andB. Samuelsson (1981)Nature 295, 327–329.Google Scholar
  41. Weiss, J.W., J.M. Drazen, N. Coles, E.J. Mcfadden, P.F. Weller, E.J. Corey, R.A. Lewis andK.F. Austen (1982)Science 216, 196–198.Google Scholar
  42. Williams, T.J., andP.J. Jose (1981)J. Exp. Med. 153, 136–153.Google Scholar
  43. Wolfe, L.S. (1982)J. Neurochem. 38, 1–14.Google Scholar
  44. Yen, S.S., andH.G. Morris (1981)Biochem. Biophys. Res. Commun. 103, 774–779.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1982

Authors and Affiliations

  • F. P. Nijkamp
    • 1
  • J. M. A. Sitsen
    • 1
  1. 1.Rudolf Magnus Institute for Pharmacology, Medical FacultyState University of UtrechtGD UtrechtThe Netherlands

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