Angiotensin converting enzyme inhibitors
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Inhibition of angiotensin converting enzyme (scace) in patients suffering from renovascular hypertension results in lowering of the blood-pressure. The development of captopril, an orally activeace inhibitor and the structure-activity relationship of captopril analogues are described. Some side effects of captopril were attributed to the presence of an SH-group in the molecule. This led to the development of a series of non-mercaptoace inhibitors derived from captopril. One of them, enalapril, a potentace inhibitor with a long duration of antihypertensive action, is now tested in clinical trials.
KeywordsPublic Health Hypertension Clinical Trial Internal Medicine Angiotensin
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