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Pharmaceutisch Weekblad

, Volume 8, Issue 4, pp 209–222 | Cite as

The beta-adrenoceptor-adenylate cyclase complex

From model to biochemical reality
  • Ad P. Ijzerman
  • Henk Timmerman
Review Articles
  • 24 Downloads

Abstract

Developments in the receptor concept have greatly influenced our current knowledge of the beta-adrenoceptor. The triad of pharmacology, organic chemistry and studies in structure-activity relationships is discussed along historical lines, as it has been and still is an impetus for progress in the biochemistry of ligand-receptor interactions. With respect to the beta-adrenoceptor complex these advances which have led to a model in which three protein structures are functionally interacting within the frame of the cell wall: the beta-adrenoceptor, the regulatory guanine nucleotide binding protein, and the enzyme adenylate cyclase, are reviewed.

Key words

Biochemistry Pharmacology Receptors, adrenergic, beta Review 

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Copyright information

© Bohn, Scheltema & Holkema 1986

Authors and Affiliations

  • Ad P. Ijzerman
    • 1
  • Henk Timmerman
    • 2
  1. 1.Division of Medicinal ChemistryCenter for Bio-Pharmaceutical SciencesRA LeidenThe Netherlands
  2. 2.Department of PharmacochemistryVrije UniversiteitHV AmsterdamThe Netherlands

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