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Pharmaceutisch Weekblad

, Volume 13, Issue 4, pp 176–178 | Cite as

Comparative bioavailability of rectal and oral formulations of chloroquine

  • Mathieu M. Tjoeng
  • Paul H. G. Hogeman
  • Harry Kapelle
  • Marcel L. J. De Ridder
  • H. Verhaar
Articles

Abstract

The relative bioavailability of chloroquinone in Witepsol® H15 suppositories can vary between 10 and 53% of the bioavailability of a tablet formulation in adults. Therefore, it is therapeutically not sound to replace chloroquine tablets by a rectal formulation with the same dose.

Keywords

Administration, oral Administration, rectal Biological availability Chloroquine Pharmacokinetics 

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References

  1. 1.
    Keystone JS. Prevention of malaria. Drugs 1990;39:337–54.PubMedGoogle Scholar
  2. 2.
    Anoniem. GHI Bulletin Malariaprofylaxe. Rijswijk: Geneeskundige Hoofdinspectie van de Volksgezondheid, 1990.Google Scholar
  3. 3.
    Weststeyn JCFM, De Geus A. Chloroquine-resistantfalciparum malaria imported into the Netherlands. Bull WHO 185;63:101–8.Google Scholar
  4. 4.
    Okor RS, Nwankwo MU. Chloroquine absorption in children from polyethylene glycol base suppositories. J Clin Pharm Ther 1988;13:219–23.PubMedGoogle Scholar
  5. 5.
    Gustafsson LL, Walker O, Alvan G, et al. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol 1983;15:471–9.PubMedGoogle Scholar
  6. 6.
    Walker O, Alvan G, Burman B, Gustafsson L, Lindström, Sjöqvist F. The pharmacokinetics of chloroquine in healthy volunteers. Br J Clin Pharmacol 1982;14(Suppl):623.Google Scholar
  7. 7.
    Frisk-Holmberg M, Bergqvist Y, Termond E, Domeij-Nyberg B. The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. Eur J Clin Pharmacol 1984;26:521–30.CrossRefPubMedGoogle Scholar
  8. 8.
    Frisk-Holmberg M, Bergqvist Y, Termond E. Further support for changes in chloroquine disposition and metabolism between a low and a high dose. Eur J Clin Pharmacol 1985;28:721–2.CrossRefPubMedGoogle Scholar
  9. 9.
    Gustafsson LL, Rombo L, Alvan G, Björkman A, Lind M, Walker O. On the question of dose-dependent chloroquine elimination of a single dose. Clin Pharmacol Ther 1983;34:383–5.PubMedGoogle Scholar
  10. 10.
    Bergqvist Y, Domeij-Nyberg B. Distribution of chloroquine and its metabolite desethylchloroquine in human blood cells and its implication for the quantitative determination of these compounds in plasma. J Chromatogr 1983;272:137–48.PubMedGoogle Scholar
  11. 11.
    Alvan G, Ekman L, Lindstrom B. Determination of chloroquine and its desethylmetabolite in plasma, red blood cells and urine by liquid chromatography. J Chromatogr 1982;229:241–54.PubMedGoogle Scholar
  12. 12.
    De Boer AG, Moolenaar F, De Leede LGJ, Breimer DD. Rectal drug administration: clinical pharmacokinetic considerations. Clin Pharmacokinet 1982;7:285–311.PubMedGoogle Scholar
  13. 13.
    Rollo IM. Drugs used in the chemotherapy of malaria. In: Goodman and Gilman's th6e pharmacological basis of therapeutics. 6th ed. New York: MacMillan Publishing 1980:1038.Google Scholar
  14. 14.
    White NJ. Clinical pharmacokinetics of antimalarial drugs. Clin Pharmacokinet 1985;10:187–215.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1991

Authors and Affiliations

  • Mathieu M. Tjoeng
    • 1
  • Paul H. G. Hogeman
    • 2
  • Harry Kapelle
    • 1
  • Marcel L. J. De Ridder
    • 1
  • H. Verhaar
    • 3
  1. 1.Clinical Pharmacy DepartmentSt. Elisabeth HospitalCP AmersfoortThe Netherlands
  2. 2.St. Elisabeth HospitalAmersfoort
  3. 3.Internal Medicine DepartmentSt. Elisabeth HospitalAmersfoort

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