European Journal of Pediatrics

, Volume 152, Issue 12, pp 1030–1035

Results of parenchymal and angiographic magnetic resonance imaging and neuropsychological testing of children after stroke as neonates

  • W. Koelfen
  • M. Freund
  • S. König
  • V. Varnholt
  • H. Rohr
  • Ch. Schultze
Neuropediatrics

Abstract

We describe the long-term follow up of infants after neonatal stroke of the middle cerebral artery (MCA). Stroke was diagnosed by CT scan in eight full-term neonates. Three dimensional (volume) magnetic resonance angiography (MRA) is a noninvasive technique that images the arterial vessels without contrast agents. All patients, aged from 1.5 to 8.4 years, were investigated by MRI and MRA and by neuropsychological tests. Cognitive development was investigated by intelligence tests, tests of visual perception, motor and language development. Out of the eight patients, seven had a retarded mental and motor development, and 50% of the children were treated for epilepsy. Seven patients had a spastic hemiparesis. Seven out of eight children showed major cognitive deficits. In all patients, MRI revealed clear parenchymal defects with variable distribution patterns. MRA studies showed abnormalities corresponding to the expected vascular distribution. Children with complications at delivery, with seizures, and an interruption of the main stem of MCA as demonstrated on MRA had the least favourable long-term follow up prognosis with severe cognitive delays.

Key words

Neonatal stroke Magnetic resonance imaging Magnetic resonance angiography Neuropsychological tests Long-term follow up 

Abbreviations

MCA

middle cerebral artery

MRA

magnetic resonance angiography

MRI

magnetic resonance imaging

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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • W. Koelfen
    • 1
  • M. Freund
    • 2
  • S. König
    • 1
  • V. Varnholt
    • 1
  • H. Rohr
    • 1
  • Ch. Schultze
    • 1
  1. 1.Department of Pediatrics, Faculty of Clinical Medicine MannheimUniversity of HeidelbergMannheimGermany
  2. 2.Department of Radiology, Faculty of Clinical Medicine MannheimUniversity of HeidelbergMannheimGermany

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