European Journal of Pediatrics

, Volume 152, Issue 4, pp 309–312 | Cite as

Cytokines predict coronary aneurysm formation in Kawasaki disease patients

  • C. -Y. Lin
  • C. -C. Lin
  • B. Hwang
  • B. N. Chiang


In this study, we measured serially the serum levels of cytokines including interleukin-6 (IL-6), IL-8, soluble IL-2 receptor (sIL-2R) and tumour necrosis factor α (TNF-α) in 60 patients with Kawasaki disease (KD) and evaluated the clinical significance of these cytokines in predicting coronary aneurysm formation. Of the 60 patients, 12 were complicated with coronary aneurysm. Blood samples were collected within the 1st week after onset of fever, then once a week for the 1st month, and once a month for another 5 months. The serum levels of IL-6, IL-8, sIL-2R and TNFα were measured using an ELISA or RIA method. Our results show that the changes in serum IL-6 and IL-8 were faster than those of sIL-2R and TNFα. Within the 1st week, the serum levels of IL-6 and IL-8 were significantly higher in the patients with than in those without coronary aneurysm (P<0.001). In addition, the serum levels of IL-6 and IL-8 obtained in the 1st week were highly correlated (P<0.001) with those of C-reactive protein and erythrocyte sedimentation rate, and the serum levels of sIL-2R and TNFα were also increased at the 1st week reaching the highest level in the 2nd week. In the 2nd week, the serum levels of sIL-2R and TNFα were significantly higher in the patients with than in those without coronary aneurysm (P<0.05). These findings suggest that the serum levels of IL-6 and IL-8 obtained in the 1st week may serve as useful parameters in predicting coronary aneurysm formation in KD patients.

Key words

Kawasaki disease Interleukin-6 Interleukin-8 Tumour necrosis factor α 



Kawasaki disease




tumour necrosis factor α




soluble interleukin-2 receptor


polymorphonuclear leucocytes


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • C. -Y. Lin
    • 1
    • 2
  • C. -C. Lin
    • 1
  • B. Hwang
    • 2
  • B. N. Chiang
    • 1
  1. 1.Medical ResearchVeterans General HospitalShih-Pai TaipeiTaiwan, Republic of China
  2. 2.Department of PaediatricsVeterans General HospitalShih-Pai TaipeiTaiwan, Republic of China

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