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Pharmaceutisch Weekblad

, Volume 9, Issue 6, pp 321–323 | Cite as

Determination of atropine in plasma by a direct radioreceptor assay

  • K. Ensing
  • R. A. De Zeeuw
  • U. Hörnchen
  • J. Schüttler
  • H. Stoeckel
Short Communications
  • 27 Downloads

Abstract

A highly sensitive radioreceptor assay for the anticholinergic atropine was developed and could be applied directly to plasma samples obtained from mini-pigs without any clean-up. Plasma samples were collected during 6 h after atropine was administered intravenously or endobronchially. The endobronchial plasma concentration-time curves were characterized by a very rapid rise of the concentration but with a subsequent much slower decrease than after intravenous administration. This indicates an initially high as well as prolonged uptake from the lungs.

Key words

Administration, endobronchial Administration, intravenous Atropine Pharmacokinetics Radioligand assay 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • K. Ensing
    • 1
  • R. A. De Zeeuw
    • 1
  • U. Hörnchen
    • 2
  • J. Schüttler
    • 2
  • H. Stoeckel
    • 2
  1. 1.Groningen Centre for Drug ResearchState University of GroningenAW Groningenthe Netherlands
  2. 2.Institute for AnaesthesiologyUniversity of BonnBonn 1Germany

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