Pharmaceutisch Weekblad

, Volume 9, Issue 1, pp 1–23 | Cite as

Penicillins and cephalosporins

Physicochemical properties and analysis in pharmaceutical and biological matrices
  • P. C. van Krimpen
  • W. P. van Bennekom
  • A. Bult
Review Articles


Penicillins and cephalosporins belong to the most prescribed antibiotics. Despite the relatively extended knowledge of these drugs, the qualitative and quantitative analysis of the compounds still gives rise to many problems. These difficulties are due to the chemical instability of the common Β-lactam nucleus, the minor differences in chemical structures between the analogues, and the complex and relatively fast degradation of the compounds in aqueous solutions. In this review a compilation of the physicochemical properties, the degradation routes and methods for analysis of these substances in biological and other matrices is presented.

Key words

Cephalosporins Chemistry, physical Chromatography Drug stability Penicillins Polarography Spectrum analysis Structure-activity relationship Titrimetry 


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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1987

Authors and Affiliations

  • P. C. van Krimpen
    • 1
  • W. P. van Bennekom
    • 1
  • A. Bult
    • 1
  1. 1.Department of Chemical Pharmacy, Section of Pharmaceutical Analysis, Subfaculty of PharmacyState University of UtrechtGH UtrechtThe Netherlands

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