European Journal of Pediatrics

, Volume 153, Issue 12, pp 903–905 | Cite as

Pulmonary effects of closure of patent ductus arteriosus in premature infants with severe respiratory distress syndrome

  • Teresa Farstad
  • Dag Bratlid
Neonatology Original Paper


The pulmonary effects of closure of a patent ductus arteriosus (PDA) were investigated in 11 premature infants with severe respiratory distress syndrome. Successful closure of a PDA did not improve the short-term severity of pulmonary disease (24 and 48 h after treatment) as judged by the arterial/alveolar oxygen tension ratio or the amount of ventilatory support. Also, pulmonary mechanics measured 24 h before, 24 and 48 h after treatment, were not statistically different.


Infants with severe respiratory disease requiring high ventilation pressure and high oxygen concentration, where structural changes in the lungs are already established, will rarely show short-term improvement in pulmonary disease as a result of closure of a PDA. The overall clinical condition may, however, improve as a result of reduced cardiovascular strain. Earlier treatment of a PDA could reduce the ventilation period and the possible risk of developing chronic lung disease.

Key words

Dynamic compliance Patent ductus arteriosus Premature infants Respiratory distress syndrome 



patent ductus arteriosus


respiratory distress syndrome


dynamic lung compliance


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  1. 1.
    Clyman RI, Mauray F, Heymann MA, Roman C (1987) Cardiovascular effects of patent ductus arteriosus in preterm lambs with respiratory distress. J Pediatr 111: 579–587Google Scholar
  2. 2.
    Cotton RB, Stahlman M, Kovar I, Catterton WZ (1987) Medical management of small preterm infants with symptomatic patent ductus arteriosus. J Pediatr 92: 467–473Google Scholar
  3. 3.
    Gerhardt T, Bancalari E (1980) Lung compliance in newborns with patent ductus arteriosus before and after surgical ligation Biol Neonate 38: 96–105Google Scholar
  4. 4.
    Greenspan J, Abbasi B, Bhutani VK (1988) Sequential changes in pulmonary mechanics in the very low birth weight (≤1000 grams) infant. J Pediatr 131: 732–736Google Scholar
  5. 5.
    Heldt GP, Pesonen ET, Merrit TA, Elias W, Sahn DJ (1989) Closure of the ductus arteriosus and mechanics of breathing in preterm infants after surfactant replacement therapy. Pediatr Res 25: 305–321Google Scholar
  6. 6.
    Hjalmarson O (1981) Epidemiology and classification of acute neonatal respiratory disorders. Acta Pædiatr Scand 70: 773–783Google Scholar
  7. 7.
    Krauss AN, Fatica N, Lewis BS, Cooper R, Thaler HT (1989) Pulmonary function in preterm infants following treatment with intravenous indomethacin. Am J Dis Child 143: 78–81Google Scholar
  8. 8.
    Mellander M, Larsson LE (1988) Effects of left-to-right ductus shunting on left ventricular output and cerebral blood flow velocity in 3-day-old preterm infants with and without severe lung disease. J Pediatr 113: 101–109Google Scholar
  9. 9.
    Stefano JL, Abbasi S, Pearlman SA, Spear ML, Esterly KL, Bhutani VK (1991) Closure of the ductus arteriosus with indomethacin in ventilated neonates with respiratory distress syndrome. Am Rev Respir Dis 143: 236–239Google Scholar
  10. 10.
    Yeh TF, Thalji A, Luken L, Lilien L, Carr I, Pildes RS (1981) Improved lung compliance following indomethacin therapy in premature infants with persistent ductus arteriosus. Chest 80: 698–700Google Scholar

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Teresa Farstad
    • 1
  • Dag Bratlid
    • 1
  1. 1.Department of PaediatricsRikshospitaletOslo 1Norway

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