European Journal of Pediatrics

, Volume 151, Issue 12, pp 870–873

Recent advances in the pathogenesis of atopic dermatitis

  • H. P. Van Bever

DOI: 10.1007/BF01954120

Cite this article as:
Van Bever, H.P. Eur J Pediatr (1992) 151: 870. doi:10.1007/BF01954120


Atopic dermatitis (AD) is an inflammatory skin disorder affecting 5%–10% of children. Although basic mechanisms remain largely speculative, recent studies on the pathogenesis have elucidated new insights, pointing to the importance of food and inhalant aller-gens. The pathogenesis of AD can be more easily explained by the model of late skin reaction occurring after mast cell activation. The present report highlights some of the more recent developments in the mechanisms of AD which can be important in understanding and treating this troublesome disease.

Key word

Atopic dermatitis 



atopic dermatitis


double-blind placebo-controlled provocation test


Fc receptor for IgE


Langerhans cell


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • H. P. Van Bever
    • 1
  1. 1.Departments of Paediatrics and ImmunologyUniversity Hospital AntwerpEdegem-AntwerpBelgium

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