A controlled clinical study compared the antipyretic effectiveness of acetaminophen administered at regular 4 h intervals (group 1,n=53) versus sproadic usage contingent upon a body temperature above 37.9°C (group 2,n=51) in 104 children presenting with simple febrile convulsions. The incidence of febrile episodes or temperature values were similar in spite of significantly larger amounts of acetaminophen administered to patients in group 1. Four and 4 children in groups 1 and 2, respectively, had a second episode of febrile seizures, in all of them within the first 24 h of admission. We conclude that the prophylactic administration of acetaminophen in children with febrile seizures is not effective in the prevention of fever, the reduction of its degree, or in preventing the early recurrence of febrile seizures.
Febrile seizures Acetaminophen
This is a preview of subscription content, log in to check access.
Lahat E, Katz Y, Bistritzer T, Eshel G, Aladjem M (1990) The incidence of febrile and non-febrile seizures in young children with shigella-associated convulsions. Ann Neurol 28:393–395CrossRefPubMedGoogle Scholar
Lewis HM, Parry JV, Parry RP, et al (1979) Role of viruses in febrile convulsions. Arch Dis Child 54:869–879PubMedGoogle Scholar
Nelson KB, Ellenberg JA (1978) Prognosis in children with febrile seizures. Pediatrics 61:720–727PubMedGoogle Scholar
Rantala H, Uhair M, Tuokko H (1990) Viral infections and recurrences of febrile convulsions. J Pediatr 116:195–199PubMedGoogle Scholar
Shirts SB, Hauser WA, Annegers JF (1987) Risk of recurrence of febrile seizures in a population based cohort of children. Neurology 37 [Suppl 1]:149PubMedGoogle Scholar
Steele WR, Tanaka TP, Lara PR, Bass WJ (1970) Evaluation of sponging and oral antipyretic therapy to reduce fever. J Pediatr 77:824–829PubMedGoogle Scholar
Torphy DE (1989) Occult bacteremia in children with simple febrile seizures. Am J Dis Child 143:273PubMedGoogle Scholar
Van Den Berg BJ, Yerushalmy J (1969) Studies on convulsive disorders in young children. Incidence of febrile and nonfebrile convulsions by age and other factors. Pediatr Res 3:298–304PubMedGoogle Scholar