European Journal of Pediatrics

, Volume 152, Issue 9, pp 704–711 | Cite as

A proposition for the diagnosis and treatment of gastro-oesophageal reflux disease in children: A report from a working group on gastro-oesophageal reflux disease

  • Y. Vandenplas
  • A. Ashkenazi
  • D. Belli
  • N. Boige
  • J. Bouquet
  • S. Cadranel
  • J. P. Cezard
  • S. Cucchiara
  • C. Dupont
  • K. Geboes
  • F. Gottrand
  • H. S. A. Heymans
  • C. Jasinski
  • C. M. F. Kneepkens
  • S. Koletzko
  • P. Milla
  • J. F. Mougenot
  • D. Nusslé
  • J. Navarro
  • S. J. Newell
  • E. Olafsdottir
  • S. Peeters
  • A. Ravelli
  • I. Polanco
  • B. K. Sandhu
  • J. Tolboom


In this paper, a Working Group on Gastro-Oesophageal Reflux discusses recommendations for the first line diagnostic and therapeutic approach of gastro-oesophageal reflux disease in infants and children. All members of the Working Group agreed that infants with uncomplicated gastro-oesophageal reflux can be safely treated before performing (expensive and often unnecessary) complementary investigations. However, the latter are mandatory if symptoms persist despite appropriate treatment. Oesophageal pH monitoring of long duration (18–24 h) is recommended as the investigation technique of choice in infants and children with atypical presentations of gastro-oesophageal reflux. Upper gastro-intestinal endoscopy in a specialised centre is the technique of choice in infants and children presenting with symptoms suggestive of peptic oesophagitis. Prokinetics, still a relatively new drug family, have already obtained a definitive place in the treatment of gastro-oesophageal reflux disease in infants and children, especially if “non-drug” treatment (positional therapy, dietary recommendations, etc.) was unsuccessful. It was the aim of the Working Group to help the paediatrician with this consensus statement and guide-lines to establish a standardised management of gastro-oesophageal reflux disease in infants and children.


Public Health Working Group Therapeutic Approach Consensus Statement Standardise Management 
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gastro-oesophageal reflux


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Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • Y. Vandenplas
    • 18
  • A. Ashkenazi
    • 1
  • D. Belli
    • 2
  • N. Boige
    • 3
  • J. Bouquet
    • 4
  • S. Cadranel
    • 5
  • J. P. Cezard
    • 3
  • S. Cucchiara
    • 6
  • C. Dupont
    • 7
  • K. Geboes
    • 8
  • F. Gottrand
    • 9
  • H. S. A. Heymans
    • 10
  • C. Jasinski
    • 11
  • C. M. F. Kneepkens
    • 12
  • S. Koletzko
    • 13
  • P. Milla
    • 14
  • J. F. Mougenot
    • 15
  • D. Nusslé
    • 2
  • J. Navarro
    • 3
  • S. J. Newell
    • 16
  • E. Olafsdottir
    • 17
  • S. Peeters
    • 18
  • A. Ravelli
    • 19
  • I. Polanco
    • 20
  • B. K. Sandhu
    • 21
  • J. Tolboom
    • 22
  1. 1.Kaplan Hospital RehovotIsrael
  2. 2.Hôpital Cantonal UniversitaireGenèveSwitzerland
  3. 3.Hôpital Robert DebréParisFrance
  4. 4.Sophia Children HospitalRotterdamThe Netherlands
  5. 5.Hôpital Universitaire Des EnfantsBruxellesBelgique
  6. 6.Universita Degli Studi di NapoliNapoliItaly
  7. 7.Hôpital Saint Vincent de PaulParisFrance
  8. 8.U.Z. GasthuisbergLeuvenBelgium
  9. 9.CHRU LilleFrance
  10. 10.Academisch Ziekenhuis GroningenGroningenThe Netherlands
  11. 11.Centro PediatricoMontevideoUruguay
  12. 12.Vrije UniversiteitAmsterdamThe Netherlands
  13. 13.Heinrich-Heine-UniversitätDüsseldorf 1Germany
  14. 14.Institute of Child HealthLondonUK
  15. 15.Hôpital des Enfants MaladesParisFrance
  16. 16.Birmingham Maternity HospitalBirminghamUK
  17. 17.BarnklinikenBergenNorway
  18. 18.Academisch Ziekenhuis Vrije Universiteit BrusselBrusselsBelgium
  19. 19.Spedali CiviliBresciaItaly
  20. 20.Universidad Autonoma de MadridMadridSpain
  21. 21.Royal Hospital St. Michaels' HillBristolUK
  22. 22.StRadboud Academisch Ziekenhuis NijmegenNijmegenThe Netherlands

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