Pharmaceutisch Weekblad

, Volume 6, Issue 2, pp 96–98 | Cite as

Prolonged storage of aminophylline suppositories

The impact on physical parameters and bioavailability
  • J. J. Tukker
  • C. J. de Blaey
Short Communications


Prolonged storage of aminophylline/cocoa butter suppositories at 30° resulted in a marked decrease in bioavailability, after administration to a panel of human volunteers. Not more than 20% of the drug content was absorbed during the first 8 hours and the maximum plasma level was obtained 5–7 hours after administration.

It was concluded that storage conditions should be considered well and storage instructions should be given to the patient.


Public Health Internal Medicine Plasma Level Marked Decrease Storage Condition 
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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • J. J. Tukker
    • 1
  • C. J. de Blaey
    • 1
  1. 1.Department of PharmaceuticsState UniversityGH UtrechtThe Netherlands

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