Pharmaceutisch Weekblad

, Volume 6, Issue 2, pp 88–90 | Cite as

On the efficacy of low dose prednisolone and heparin sodium in the prevention of infusion thrombophlebitis. A double-blind trial

  • C. de Cock
  • P. Vermeij
  • Th. Stijnen
Original Articles


A prospective, double-blind investigation into the effectiveness of the addition to infusion fluids of an injectable containing 0.3 mg prednisolone and 10 units heparin per ml in a phosphate buffer pH=7·5 versus the phosphate buffer alone is described. 196 Patients were allocated alternately to each group. On a total number of 593 cannulation days, 16 cases of thrombophlebitis were diagnosed. Statistical evaluation revealed a significant difference between the two groups (p<0.01) in favour of prednisolone + heparin sodium.


Public Health Sodium Phosphate Internal Medicine Phosphate Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Elfving G, Hästbacka J. Infusion thrombophlebitis and its prevention. Am Heart J 1967;73:717–8.CrossRefPubMedGoogle Scholar
  2. 2.
    Hoshal VL, Ause RG, Hokins PA. Fibrin sleeve formation on indwelling central venous catheters. Arch Surg 1971;102:353–8.Google Scholar
  3. 3.
    Henzel JH, De Weese MS. Morbid and mortal complications associated with prolonged central venous cannulation. Am J Surg 1971;121:600–5.CrossRefPubMedGoogle Scholar
  4. 4.
    Maki DG, Goldman DA, Rhane FS. Infection control in intravenous therapy. Ann Intern Med 1973;79:867–86.PubMedGoogle Scholar
  5. 5.
    Hop WCJ, Hermans J. Statistische analyse van overlevingsduren. Tijdschr Soc Geneeskd 1981;59:279–88.Google Scholar
  6. 6.
    Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Br J Cancer 1977;35:1–35.PubMedGoogle Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • C. de Cock
    • 1
  • P. Vermeij
    • 1
  • Th. Stijnen
    • 2
  1. 1.Andreas HospitalNR AmsterdamThe Netherlands
  2. 2.Department of Medical StatisticsState University of LeidenAL Leiden

Personalised recommendations